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Article Abstract
Nitrogen-containing heteroaromatic cores are ubiquitous building blocks in organic chemistry. Herein, we present a family of metal-free intermolecular formal cycloaddition reactions that enable highly selective and orthogonal access to isoquinolines and pyrimidines at will. Applications of the products are complemented by a density functional theory mechanistic analysis that pinpoints the crucial factors responsible for the selectivity observed, including stoichiometry and the nature of the heteroalkyne.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796318 | PMC |
| http://dx.doi.org/10.1038/ncomms10914 | DOI Listing |
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