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The current work sought to operationalize constructs of the triarchic model of psychopathy in chimpanzees (), a species well-suited for investigations of basic biobehavioral dispositions relevant to psychopathology. Across three studies, we generated validity evidence for scale measures of the triarchic model constructs in a large sample (=238) of socially-housed chimpanzees. Using a consensus-based rating approach, we first identified candidate items for the chimpanzee triarchic (CHMP-Tri) scales from an existing primate personality instrument and refined these into scales. In Study 2, we collected data for these scales from human informants (=301), and examined their convergent and divergent relations with scales from another triarchic inventory developed for human use. In Study 3, we undertook validation work examining associations between CHMP-Tri scales and task measures of approach-avoidance behavior (=73) and ability to delay gratification (=55). Current findings provide support for a chimpanzee model of core dispositions relevant to psychopathy and other forms of psychopathology.
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http://dx.doi.org/10.1177/2167702615568989 | DOI Listing |
PLoS Pathog
September 2025
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Hepatitis C virus (HCV) exhibits a narrow species tropism, causing robust infections only in humans and experimentally inoculated chimpanzees. While many host factors and restriction factors are known, many more likely remain unknown, which has limited the development of mouse or other small animal models for HCV. One putative restriction factor, the black flying fox orthologue of receptor transporter protein 4 (RTP4), was previously shown to potently inhibit viral genome replication of several ER-replicating RNA viruses.
View Article and Find Full Text PDFJ Virol
September 2025
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Hepatitis C virus (HCV) is an enveloped, positive-sense single-stranded RNA virus causing chronic infections in over 50 million people who are at risk of developing severe liver disease. Greater understanding of HCV pathogenesis and vaccine development has been hampered by the lack of a fully immunocompetent small-animal model permissive to infection. Rodents are resistant to HCV infection due to a variety of factors at the levels of entry and replication, many of which have been discovered within the past decade.
View Article and Find Full Text PDFSci Rep
September 2025
Laboratory of Quantum and Statistical Physics LR 18 ES 18, Faculty of Sciences of Monastir, University of Monastir, Environnement Street, 5019, Monastir, Tunisia.
A new finite multi-layer model coupled with real gas law is successfully established using statistical physics theory and applied to theoretically characterize the docking process of vanillin key food odorant on human hOR8H1, chimpanzee cOR8H1, and horse hoOR8H1 olfactory receptors. To deeply comprehend and analyze the mechanism of adsorption involved in the sense of smell, stereographic, van der Waals, and energetic metrics are interpreted. Indeed, modeling findings reveal that the vanillin molecules are non-parallelly docked on the binding sites of the three mammalian olfactory receptors.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2025
Department of Psychology, Princeton University, Princeton, NJ 08544.
Vocal development in human infants is strongly influenced by interactions with caregivers who reinforce more speech-like sounds. This trajectory of vocal development in humans is radically different from those of our close phylogenetic relatives, cercopithecoid monkeys and apes. In these primates, social feedback seems to play no significant role in their vocal development.
View Article and Find Full Text PDFSci Rep
July 2025
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, USA.
A subset of imprinting control regions (ICRs) in the human and mouse possess CpG islands associated with imperfect tandem repeats (TRs) that were shown to be essential for genomic imprinting through genetic studies. To identify whether this feature is also present in non-imprinted CpG island promoters, we performed extensive dot plot analyses and identified 342 (326 autosomal and 16 X-chromosomal) human CpG island gene promoters associated with imperfect TRs of ≥ 400 bp, unit lengths 50-150 bp. Most occur as clusters at the human chromosome ends, distinct from the clusters of imprinted genes, and enriched in neurodevelopmental/behavioral disorders, with some showing interindividual variation in methylation levels.
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