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Freezing of gait (FOG) is a common motor impairment to suffer an inability to walk, experienced by Parkinson's disease (PD) patients. FOG interferes with daily activities and increases fall risk, which can cause severe health problems. We propose a novel smartphone-based system to detect FOG symptoms in an unconstrained way. The feasibility of single device to sense gait characteristic was tested on the various body positions such as ankle, trouser pocket, waist and chest pocket. Using measured data from accelerometer and gyroscope in the smartphone, machine learning algorithm was applied to classify freezing episodes from normal walking. The performance of AdaBoost.M1 classifier showed the best sensitivity of 86% at the waist, 84% and 81% in the trouser pocket and at the ankle respectively, which is comparable to the results of previous studies.
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http://dx.doi.org/10.1109/EMBC.2015.7319209 | DOI Listing |
Cureus
August 2025
Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, USA.
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms such as tremor, its impact on FoG is less clear. Rarely, STN-DBS itself can induce FoG.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
UCL Queen Square Institute of Neurology, London, UK.
Background: Progressive Supranuclear Palsy (PSP) is a rare and severe neurodegenerative tauopathy characterized by diverse clinical phenotypes, including Richardson's syndrome (PSP-RS), PSP-parkinsonism (PSP-P), PSP-progressive gait freezing (PSP-PGF), and PSP-corticobasal syndrome (PSP-CBS). Significant geographic variation exists in prevalence, clinical presentations, and prognosis.
Objectives: This global review aims to systematically evaluate the epidemiological variation, clinical phenotypes, diagnostic practices, and management strategies for PSP, focusing on regional disparities and identifying influencing genetic and environmental factors.
Front Psychol
August 2025
Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States.
Introduction: Interlimb coordination, the synchronization of movements between limbs, is essential for efficient and stable human movement. Disruptions in coordination contribute to gait dysfunction, a common challenge for individuals with Parkinson's disease (PD). This scoping review investigates how PD impairs interlimb coordination and influences gait adaptability, emphasizing the complexity of motor control challenges.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
September 2025
Patients with severe Parkinson's disease (PD) frequently have freezing of gait (FOG), a gait disability. By anticipating FOG before it occurs, pre-emptive cueing can either prevent FOG or lessen its severity and duration. To improve the accuracy of FOG detection, both electroencephalography (EEG) data and other complementary modalities, such as gait-based data, are increasingly being explored.
View Article and Find Full Text PDFAge Ageing
August 2025
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Background: Although recent evidence suggests that glycemic variability (GV) has a negative impact on neurodegeneration, its role in Parkinson's disease (PD) remains unclear.
Objective: To explore the association between long-term GV and longitudinal motor and nonmotor progression in patients with PD and to uncover the disease-specific and nonspecific mechanisms underlying this association.
Methods: We used data obtained from the Parkinson's Progression Markers Initiative cohort.