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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145555 | PLOS |
Mol Biol Rep
September 2025
Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Aim: Ischemia-reperfusion (IR) injury-induced renal failure is a major cause of death and morbidity. Unfortunately, there is currently no proven protective therapy. The aim of the study is to investigate the protective effect of D-carvone against the renal ischemia-reperfusion (RIR) injury.
View Article and Find Full Text PDF: Sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection) causes millions of deaths worldwide annually. Sepsis-induced changes in brain regulatory functions remain understudied. Previous work demonstrated that cecal ligation and puncture (CLP, a murine model of sepsis) affected physiologic variables and serum cytokines and hormone levels.
View Article and Find Full Text PDFDig Dis Sci
September 2025
School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, China.
Int J Mol Sci
August 2025
Department of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
Cardiovascular disease (CVD) remains the leading global cause of morbidity and mortality, largely driven by atherosclerosis, a chronic inflammatory process involving lipids and immune cells. Although traditional lipid biomarkers such as low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are well-established in CVD risk stratification, the interplay between cytokines, chemokines, growth factors (CCGFs), lipid metabolism, and hematological parameters in non-cardiac populations remains underexplored. We investigated associations between plasma cytokines and lipid-related biomarkers and their relationships with circulating blood cell counts in a cohort of 164 essentially healthy adults aged 18-44 years.
View Article and Find Full Text PDFEur J Pharmacol
August 2025
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines, Ministry of Education, Beijing, 100193, China; Beijing Key Laboratory of
Cerebral ischemia/reperfusion injury (CIRI) poses a significant threat to human life and health. Ginsenoside Rb3 (Rb3) is known to exhibit protective effects against myocardial ischemia, its impact on CIRI remains unclear. Therefore, we investigated the protective effects of Rb3 on CIRI and its underlying mechanisms.
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