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http://dx.doi.org/10.1016/j.acra.2015.09.006 | DOI Listing |
J Am Coll Radiol
September 2025
Chair, Department of Radiology, Northwestern University Feinberg School of Medicine, Northwestern Medicine, Chicago, IL, USA.
Introduction: Incidental findings in radiology are common, especially with rising imaging volumes. Early disease recognition can greatly improve clinical outcomes, but in low-risk cases, incidental findings often lead to overdiagnosis and overtreatment, causing harm. Robust systems are critical to promote early identification without overburdening patients or healthcare systems.
View Article and Find Full Text PDFJAMA Netw Open
August 2025
Centre for Cancer Screening, Prevention, and Early Detection, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Importance: Cancer screening is a critical tool in cancer control, reducing cancer-specific mortality. However, it also has potential harms, including overdiagnosis and overtreatment. Measuring the effect of screening based on all-cause mortality is insensitive to both benefits and harms and requires substantially large sample sizes.
View Article and Find Full Text PDFBackground: Blood-based gene signatures offer potential as a near point-of-care tuberculosis (TB) screening tool. We examined the accuracy of the GeneXpert MTB Host Response (Xpert-HR) cartridge to screen for TB in children.
Methods: We enrolled children under 15 years from The Gambia and Uganda being evaluated for pulmonary TB.
Diagnostics (Basel)
July 2025
Department of Medical Science, Surgery and Neurosciences, Urgency-Emergency Anesthesia and Intensive Care Unit, University Hospital of Siena, 53100 Siena, Italy.
Lower respiratory tract infections remain a leading cause of morbidity and mortality among Intensive Care Unit patients, with severe cases often progressing to acute respiratory distress syndrome (ARDS). This life-threatening syndrome results from alveolar-capillary membrane injury, causing refractory hypoxemia and respiratory failure. Early detection and management are critical to treat the underlying cause, provide protective lung ventilation, and, eventually, improve patient outcomes.
View Article and Find Full Text PDFMed Phys
August 2025
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Background: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) share overlapping characteristics on magnetic resonance imaging (MRI), confounding the diagnosis and detection of PCa. There is thus a clinical need to accurately differentiate BPH-Only from BPH-PCa to prevent overdiagnosis and unnecessary biopsies. Although BPH and PCa may share overlapping features, they are distinct clinical entities.
View Article and Find Full Text PDF