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http://dx.doi.org/10.1186/s12931-015-0289-0 | DOI Listing |
Am J Physiol Regul Integr Comp Physiol
September 2025
United States Army Research Institute of Environmental Medicine, Natick, MA, US.
Unlabelled: Insulin resistance has been associated with acute mountain sickness (AMS) risk, but the influence of active ascent is unclear.
Methods: Thirty-two unacclimatized Soldiers (23±4yr; 80±14 kg) were tested at baseline residence (BLR), hiked ~5 km (n=16) or were driven (n=16) to 4,300 m, and stayed for 4 days (~66 h). Venous blood was taken each morning at BLR and during high altitude (HA) exposure days 2-4 (HA2-4) and the evening on day 1 at HA (HA1).
Front Cell Infect Microbiol
September 2025
Universidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.
Natural killer (NK) cells are innate lymphocytes with cytotoxic activity against tumors and viruses. The pandemic of the coronavirus disease 2019 (COVID-19) has increased the investigation of their role in disease severity. However, their functional status and modulators remain controversial.
View Article and Find Full Text PDFAm J Emerg Med
September 2025
University of South Carolina School of Medicine - Greenville, Greenville, SC, USA.
Total laryngectomy (TLE) results in the permanent separation of the respiratory and digestive tracts, requiring all airway interventions to occur exclusively via a neck stoma. Although airway obstruction in post-laryngectomy patients is uncommon, it can rapidly become fatal without prompt recognition and understanding of the altered anatomy. Here, we report the case of a patient with a recent TLE for squamous cell carcinoma, who presented to a rural Emergency Department (ED) in acute respiratory distress.
View Article and Find Full Text PDFJCI Insight
September 2025
Department of Physiology and Neurobiology, University of Connecticut, Storrs, United States of America.
Dravet syndrome (DS) is an early-onset epilepsy caused by loss of function mutations in the SCN1A gene, which encodes Nav1.1 channels that preferentially regulate activity of inhibitory neurons early in development. DS is associated with a high incidence of sudden unexpected death in epilepsy (SUDEP) by a mechanism that may involve respiratory failure.
View Article and Find Full Text PDFOncologist
September 2025
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Belzutifan is a HIF-2ɑ inhibitor approved for the treatment of tumors in von Hippel-Lindau (VHL) syndrome and sporadic metastatic clear cell renal cell carcinoma (spRCC) in the refractory setting. The efficacy and side effects of belzutifan are well-documented from clinical trials, however, real-world data examining the incidence and management of adverse events (AEs) are lacking. Our study aims to describe the AE profiles of belzutifan in spRCC and VHL populations.
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