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We present a 60-year-old male patient who, three months after a holiday in Southern Greece, found a small 'pimple' on his back, which gradually got as big as a small walnut, the central part becoming ulcerated and scabby. Dermatological examination found an erythematous-to-livid nodular lesion on the right shoulder; it was 16 mm in diameter with central ulceration, covered with brownish crust which discharged pus-like secretion upon pressure. Microscope examination of Romanowsky-Giemsa stained lesion material detected amastigote forms of Leishmania tropica. The culture investigation and serological tests for leishmaniasis were negative. Dermoscopy of the lesion found the following features: erythema, hyperkeratosis, central ulceration covered with brownish crust, "yellow tears-like" structures and "white starburst-like" patterns, and various vascular structures (including dotted vessels, comma-shaped vessels, hairpin- and glomerular-like vessels). The patient was diagnosed with cutaneous leishmaniasis and underwent four cryotherapy sessions every other week with excellent therapeutic results - complete resolution of infiltrate with subsequent gentle hypopigmented scarring. In conclusion, dermoscopy is an easily accessible non-invasive method which can be useful for the diagnosis of cutaneous leishmaniasis. Cryotherapy is the treatment of choice for single skin lesions.
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http://dx.doi.org/10.1515/folmed-2015-0021 | DOI Listing |
Chem Biol Drug Des
September 2025
Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil.
Leishmaniasis, a disease caused by Leishmania parasites, poses a significant health threat globally, particularly in Latin America and Brazil. Leishmania amazonensis is an important species because it is associated with both cutaneous leishmaniasis and an atypical visceral form. Current treatments are hindered by toxicity, resistance, and high cost, driving the need for new therapeutic targets and drugs.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Laboratório de Parasitos e Vetores, Departamento de Ciências Farmacêuticas, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, Brazil. Electronic address:
Ethnopharmacological Relevance: Schinus genus plants have a long history of use in traditional medicine, particularly in South America. The ethnopharmacological applications of Schinus species include antiseptic, antiplasmodial, antimalarial and antileishmanial properties.
Aim Of The Study: In the present work, we investigated the action of essential oil (EO) against cutaneous leishmaniasis causing agent Leishmania amazonensis in promastigote and amastigote forms as well as cytotoxicity against host cells.
J Parasit Dis
September 2025
Divisão de Parasitologia, Instituto Evandro Chagas (IEC), Belém, Pará Brazil.
Unlabelled: The study aimed to identify phlebotomine species associated with American Cutaneous Leishmaniasis (ACL) transmission in Ulianópolis, Brazil, examining their relationship with deforested areas. Using CDC light traps, 1,676 phlebotomine were collected, with a composition of 43% males and 57% females, identifying thirteen species, with and as the most prevalent. Despite the limited clinical relevance of , its substantial prevalence raised concerns regarding potential transmission of spp.
View Article and Find Full Text PDFMed Microbiol Immunol
September 2025
Instituto de Patología Experimental, Universidad Nacional de Salta/Consejo Nacional de Investigaciones Científicas y Técnicas, Salta, Salta, Argentina.
Medicine (Baltimore)
August 2025
Department of Field Crops, Food and Agriculture Vocational School, Çankiri Karatekin University, Çankiri, Turkey.
Leishmaniasis is a serious infectious disease caused by Leishmania parasites, predominantly affecting tropical and subtropical regions. These parasites replicate within macrophages, manipulating the host immune response and facilitating infection progression. While long non-coding RNAs (lncRNAs) are known regulators of immune function, their time-dependent roles during Leishmania major infection remain unclear.
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