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Article Abstract
Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients.
Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry.
Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55-68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23-100.48).
Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549758 | PMC |
| http://dx.doi.org/10.2217/fon.15.249 | DOI Listing |
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Urotensin II receptor expression in prostate cancer patients: A new possible marker.
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Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
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