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Background: We present a patient with primary amenorrhea and a rare combination of anomalies. She was found to have a septate uterus, double cervix, and a longitudinal and a low transverse vaginal septum.
Case: An 18-year-old girl with primary amenorrhea presented with severe monthly pelvic pain. Examination and imaging revealed a thin transverse vaginal septum, complete septate uterus, double cervix, and a longitudinal vaginal septum. The transverse and longitudinal vaginal septa were excised and repaired.
Summary And Conclusion: Although repetitive pregnancy loss and preterm birth are associated with various Müllerian duct anomalies, clinicians should also be suspicious of the presented anomaly in cases of primary amenorrhea and cyclic pelvic pain. To our knowledge, this is the only case of simultaneous septate uterus with longitudinal and transverse vaginal septum and the second case of combined longitudinal and transverse septum, which caused primary amenorrhea. This rare anomaly further supports the bidirectional regression theory of Müllerian development.
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http://dx.doi.org/10.1016/j.jpag.2015.04.012 | DOI Listing |
Arch Gynecol Obstet
September 2025
Department of Obstetrics and Gynecology, Academic Hospital Cologne Weyertal, Cologne, Germany.
Objective: To evaluate the safety, adhesion rates, and perioperative outcomes of monopolar and bipolar electrosurgical hysteroscopic metroplasty in women with a septate uterus.
Methods: We conducted a single-center retrospective analysis of 155 consecutive patients who underwent same-session laparoscopy and hysteroscopic septum resection between January 2021 and January 2025. Procedures were performed under surgeon discretion using either a monopolar loop with glycine distension or a bipolar loop with isotonic Ringer's lactate.
Eur J Obstet Gynecol Reprod Biol
August 2025
Department of Obstetrics and Gynecology, Hospital Foch, 92150 Suresnes, France; UFR Simone Veil, University of Versailles, Saint-Quentin-en-Yvelines- Paris Saclay, 78000 Versailles, France.
Objective: The uterine septum is the most common uterine malformation, associated with increased risk of early miscarriage and preterm birth. The benefits of surgical resection remain debated. We compared pregnancy outcomes before and after hysteroscopic septum resection within the same patients.
View Article and Find Full Text PDFCureus
July 2025
Department of Radiology, Rabat Children's Hospital, Rabat, MAR.
Complex Müllerian anomalies, such as a complete septate uterus (U2b), cervical duplication (C2), and a non-obstructive longitudinal vaginal septum (V1), are rare malformations with intricate embryological origins. They often remain undiagnosed in the absence of specific clinical symptoms. This case highlights the diagnostic value of pelvic magnetic resonance imaging (MRI) and the therapeutic benefit of personalized surgical management.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
August 2025
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
Objective: The benefits of surgical treatment of uterine septum malformation have recently been questioned. The aim of our study is to compare pregnancy outcomes following hysteroscopic resection of minor versus major septum.
Methods: A retrospective cohort study was conducted at a single tertiary university-affiliated medical center.
Cureus
July 2025
Department of Obstetrics and Gynecology, Keiyu Hospital, Yokohama, JPN.
Placental attachment spanning from the anterior to the posterior uterine wall, resulting in the formation of two uterine cavities, presents a diagnostic challenge in obstetrics. Differential diagnoses include placental abruption, multiple gestations, placental variations, and uterine anomalies. Accurate prenatal identification is often difficult, especially when anomalies are not detected during early pregnancy.
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