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Purpose: To compare the functional outcomes of nerve grafts and nerve transfers in the management of isolated musculocutaneous nerve (MCN) injuries.
Methods: We performed a retrospective case-control study of isolated MCN injury managed at a tertiary care center. The study group was composed of 12 patients managed with double nerve transfer whereas the 8 patients in the grafted group constituted the control group.
Results: In the study group, stab and missile injuries constituted most cases with a denervation period ranging between 3 and 9 months. Eleven patients in this group experienced a full range of active elbow flexion whereas one had antigravity flexion of 120°. Electromyography revealed the first sign of reinnervation of biceps at 10 ± 2 weeks, compared with 20 ± 2 weeks in the grafted group. The overall trend was for patients in the study group to have earlier return of active elbow flexion and better restoration of elbow flexion strength and range of (presumably active) elbow motion than those treated with grafting, although none of these measures reached statistical significance.
Conclusions: We found that distal nerve transfer was a superior method of managing isolated MCN injury compared with conventional nerve grafting.
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http://dx.doi.org/10.1016/j.jhsa.2015.06.122 | DOI Listing |
Laryngoscope
September 2025
Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology/Head and Neck Surgery, University of North Carolina, North Carolina, USA.
The choice of a donor nerve to innervate a free gracilis muscle transfer (FMGT) is more complicated in patients with a history of previous facial paralysis surgeries. This case report describes the use of the deep temporal nerve to successfully power a FMGT in a nerve-depleted patient.
View Article and Find Full Text PDFPlast Reconstr Surg
September 2025
Department of Surgery, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Background: Poor recovery of active glenohumeral external rotation (aGHER) after brachial plexus birth injury (BPBI) is common. Late spinal accessory nerve to infraspinatus motor branch (SAN-IS) transfer has been reported as effective. We investigated its efficacy in children over 4 years with BPBI.
View Article and Find Full Text PDFAnn Plast Surg
September 2025
From the Department of Plastic Surgery, Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN.
Background: Loss of breast sensation following mastectomy and reconstruction significantly impacts quality of life, influencing body image, intimacy, and overall emotional well-being. Despite advances in reconstructive techniques, sensory outcomes remain inconsistent, limiting broader clinical adoption of reinnervation strategies. This educational review synthesizes the current scope of sensory restoration in breast reconstruction, examining approaches to reinnervation, sensory outcome measures, and management of patient expectations.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Haihe Laboratory of Cell Ecosystem, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center fo
Persistent overactivation of the renal sympathetic nervous system drives kidney inflammation and fibrosis. Macrophages contribute to fibrogenesis by secreting various pro-fibrogenic mediators. However, whether the sympathetic nervous system regulates renal fibrosis by modulating macrophage-fibroblast interaction remains unclear.
View Article and Find Full Text PDFNeural Regen Res
September 2025
Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.
Stroke and traumatic brain injury lead to upper motor neuron syndrome, which is characterized by muscle spasticity or paresis of varying severity depending on the lesion's location and extent. Current treatments are mostly symptomatic with limited efficacy and significant side effects. Nerve transfer techniques, such as the contralateral L4 ventral root transfer in animal models and C7 root transfer in both animal and clinical studies, have been shown to reduce spasticity and improve function in upper motor neuron syndrome; however, they lack selectivity.
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