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Uncovering a novel role of nAChRs in oxidative stress-mediated vascular dysfunction in COPD.
Redox Biol
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Department of Medicine, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain; Instituto Investigación Sanitaria-Princesa IIS-IP, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Electronic
Tobacco smoke is the main risk factor for the development of chronic obstructive pulmonary disease (COPD). Despite current therapies alleviate symptoms there are limitations in the efficacy of treatments to curb its cardiovascular morbidities, particularly vascular dysfunction and the development of pulmonary hypertension. Our previous studies demonstrate that cigarette smoke directly contributes to pulmonary arterial dysfunction.
View Article and Find Full Text PDFSparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer.
J Pathol
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Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and HER2, and remains one of the most aggressive and therapeutically challenging breast cancer subtypes, marked by early relapse, metastasis, and limited targeted treatment options. In a recent study published in The Journal of Pathology, Kuo et al provide compelling evidence that nicotine exposure, whether from tobacco smoke or e-cigarette vapor, drives TNBC progression by promoting stem-like and metastatic phenotypes. Integrating clinical datasets, patient tissues, cell lines, and in vivo models, the authors demonstrate that nicotine enhances tumor aggressiveness via coordinated upregulation of CHRNA9 and IGF1R.
View Article and Find Full Text PDFEffects of different selenium fertilizer types and dosages on non-volatile organic acids and aroma substances of flue-cured tobacco.
Front Plant Sci
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College of Agriculture, South China Agricultural University, Guangzhou, China.
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View Article and Find Full Text PDFAssociation Between Mental Health Status and Nicotine Dependence Among Adult Cigarette Smokers Attending Primary Health Care Centers in Taif City, Saudi Arabia.
Cureus
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Public Health, High Institute of Public Health, Alexandria University, Alexandria, EGY.
Background: Smoking cigarettes is increasingly becoming a strong focus of concern for public health in Saudi Arabia, especially with the rise in mental health disorders. This research explores how depression, anxiety, and stress are related to the level of dependence on nicotine.
Methods: This cross-sectional study involved 310 adult smokers and utilized face-to-face interviews to collect data on participants' sociodemographic and lifestyle factors, nicotine dependence through the Fagerstrom Test of Nicotine Dependence (FTND), and mental health status using a validated Arabic version of the short form of the Depression Anxiety Stress Scales (DASS-21).
Awareness of and support for banning e-cigarettes and heated tobacco products among Mexicans who smoke.
Rev Panam Salud Publica
September 2025
Department of Health Promotion, Education and Behavior Arnold School of Public Health University of South Carolina Columbia USA Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, USA.
Objective: This study investigates awareness of and support for Mexico's bans on e-cigarettes and heated tobacco products among adults who smoke.
Methods: Data were analyzed from a 2020 survey of adult Mexicans who exclusively smoked cigarettes ( = 1 324) or smoked cigarettes and used e-cigarettes ( = 654). Weighted multilevel mixed-effects logistic regression models estimated crude and adjusted odds ratios (AORs) for awareness of and support for bans on each product, regressing these outcomes on variables for sociodemographic characteristics, product use, perceptions of harms, norms and exposure to advertising.