Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: The pharmacological self-management of novel psychoactive substance (NPS)-induced psychopathological consequences represents a fast growing phenomenon. This is facilitated by the frequent sharing of NPS intake experiences online and by the ease of access to a range of psychotropic medications from both the online and street market. Olanzapine is anecdotally reported by Web users to be the most frequent self-prescribed medication to cope with NPS-induced psychoses. Hence, we aimed here at better assessing olanzapine use/misuse for this purpose.
Methods: Exploratory qualitative searches of 163 discussion fora/specialized websites have been carried out in four languages (English, German, Spanish, and Italian) in the time frame November 2012-2013.
Results: Most NPS-users allegedly self administer with olanzapine to manage related psychotic crises/"bad trips". This may be typically taken only for a few days, at a dosage range of 5-50 mg/day.
Conclusions: Only a few research studies have formally assessed the effectiveness of olanzapine and indeed of other second-generation antipsychotics to treat NPS-induced psychosis. Olanzapine was suggested here from a range of pro drug websites as being the "ideal" molecule to terminate "bad trips". Health professionals should be informed about the risks related to olanzapine misuse.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hup.2431 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Site-specific assessment of illicit drug consumption patterns in South Korea via wastewater-based epidemiology.
Water Res
August 2025
Department of Civil and Environmental Engineering, Pusan National University, Busan 46241, Republic of Korea; Institute for Environment and Energy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:
Wastewater-based epidemiology (WBE) is increasingly used as a complementary tool for monitoring drug use at the population level, providing anonymized, real-time estimates of community drug consumption. Site-specific applications of WBE can identify localized patterns that national or municipal surveys may overlook. This study presents the first comprehensive, site-specific assessment of illicit drug use in South Korea using WBE.
View Article and Find Full Text PDFBiased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents.
Addict Neurosci
December 2024
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA.
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [1]. Despite this, there are currently only 3 FDA approved pharmacological approaches for the treatment of AUDs in the United States. The neurotensin (Nts) system has long been implicated in modulating behaviors associated with alcohol misuse.
View Article and Find Full Text PDFActivation of Kv7.2/3 channels in the PL-NAcc circuit attenuates methamphetamine-associated contextual memory.
Prog Neuropsychopharmacol Biol Psychiatry
September 2025
Department of Anatomy and Neurobiology, School of Basic Medicine, Shandong University, Jinan, Shandong, China. Electronic address:
Methamphetamine (METH), a powerful psychoactive substance, promotes the formation of the persistent drug-associated memories that have a significant contribution to relapse in drug addiction. The reward circuit of prelimbic cortical (PL) to the nucleus accumbens core (NAcc) is closely related to METH-associated contextual memory. To evaluate METH-associated contextual memory, we employed the conditioned place preference (CPP) paradigm.
View Article and Find Full Text PDFPhytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management.
Pharmaceuticals (Basel)
July 2025
Institute for Research and Community Service, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, Indonesia.
: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood pressure, and weight; however, their use is limited by genitourinary infections and ketoacidosis. Phytocannabinoids-bioactive compounds from -exhibit multi-target pharmacology, including interactions with cannabinoid receptors, Peroxisome Proliferator-Activated Receptors (PPARs), Transient Receptor Potential (TRP) channels, and potentially SGLT2. : To evaluate the potential of phytocannabinoids as novel modulators of renal glucose reabsorption via SGLT2 and to compare their efficacy, safety, and pharmacological profiles with synthetic SGLT2 inhibitors.
View Article and Find Full Text PDFIdentification of Novel THC Analogs: Chloro Derivatives of Hexahydrocannabinol and Tetrahydrocannabibutol Butanoate in an Oil Product Obtained in Japan.
Drug Test Anal
July 2025
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Since around 2021, products such as e-cigarette liquid cartridges, herbal products, and gummy products, claiming to contain tetrahydrocannabinol (THC) analogues, have been seen for sale on the internet. Recently, products claiming to contain other THC derivatives have appeared. In this study, we identified the ingredients in products distributed on the internet that claim to contain THC derivatives.
View Article and Find Full Text PDF