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One of the largest detriments in the abalone aquaculture industry is the inherently low growth rate of this marine gastropod. In order to confront this issue, greater molecular knowledge is needed on growth traits. Therefore, transcriptome analyses were performed using RNA-Seq for groups of California red abalones (Haliotis rufescens) cultured under the same conditions, but with high growth rates (HGR) or low growth rates (LGR). De novo assembly generated 44312 contigs used as references for RNA-Seq analysis. Results showed a total of 1437 differentially expressed contigs, among which, 435 were up-regulated in the HGR group and 1002 in LGR individuals. Overall, LGR abalones evidenced a greater number of exclusive transcripts and differentially transcribed genes. These results provide a valuable resource of novel transcripts in this species and further understandings of the molecular bases regulating growth traits in H. rufescens.
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http://dx.doi.org/10.1016/j.margen.2015.05.009 | DOI Listing |
Nature
September 2025
Centre for Evolution and Cancer, Institute of Cancer Research, London, UK.
Cancer development and response to treatment are evolutionary processes, but characterizing evolutionary dynamics at a clinically meaningful scale has remained challenging. Here we develop a new methodology called EVOFLUx, based on natural DNA methylation barcodes fluctuating over time, that quantitatively infers evolutionary dynamics using only a bulk tumour methylation profile as input. We apply EVOFLUx to 1,976 well-characterized lymphoid cancer samples spanning a broad spectrum of diseases and show that initial tumour growth rate, malignancy age and epimutation rates vary by orders of magnitude across disease types.
View Article and Find Full Text PDFPhotobiomodul Photomed Laser Surg
September 2025
Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
The current study sought to explore the impact of a novel noninvasive treatment called transcranial photobiomodulation (PBM) on resting-state functional connectivity (rsFC) of the cerebellum in individuals with a history of repetitive head acceleration events (RHAEs). RHAEs are associated with cumulative neurological compromise, including chronic alterations in rsFC; however, few treatments have been investigated to mitigate these effects. A recent study by our team demonstrated that PBM treatment led to improvements in measures of balance and motor function in adults with RHAE exposure.
View Article and Find Full Text PDFCase Rep Genet
September 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of California, Irvine, California, USA.
Nonimmune hydrops fetalis (NIHF) refers to the pathologic accumulation of fluid within the fetus due to causes other than red cell alloimmunization and now accounts for up to 90% of fetal hydrops cases. Fetal hydrops is associated with significant morbidity and mortality, and the exact prognosis is largely dependent on the underlying etiology. The most common etiologies include cardiovascular causes and chromosomal or genetic abnormalities.
View Article and Find Full Text PDFNat Commun
September 2025
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Proc Biol Sci
September 2025
Division of Integrative Anatomical Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Red blood cell (RBC) size constrains the rate of diffusion of gases between (i) the environment and the capillary beds of the gas exchanger and (ii) the blood and organs. In birds, small RBCs with a high surface area to volume ratio permit a high O diffusion capacity and facilitate sustained, vigorous exercise. Unfortunately, our knowledge of archosaur cardiovascular evolution is incomplete without fossilized RBCs and blood vessels.
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