Objective cerebrospinal fluid response to intraventricular rituximab in indolent CNS lymphoma.

CNS Oncol

Department of Neurology, Johns Hopkins Hospital, David H. Koch Cancer Research Bldg II, 1550 Orleans Street, Room 1M16, Baltimore, MD 21287, USA.

Published: February 2016


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Article Abstract

Indolent CNS lymphomas (CNSLs) are rare and no guidelines exist for management. Recent literature highlights the potential for safe and tolerable intrathecal (IT) delivery of rituximab, a large anti-CD20 monoclonal antibody, for aggressive CNSL. We report a patient with relapsed indolent CNSL who failed systemic rituximab and could not tolerate IT chemotherapies, but had an objective response of 6 months duration to IT rituximab.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778415PMC
http://dx.doi.org/10.2217/cns.15.3DOI Listing

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