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Indolent CNS lymphomas (CNSLs) are rare and no guidelines exist for management. Recent literature highlights the potential for safe and tolerable intrathecal (IT) delivery of rituximab, a large anti-CD20 monoclonal antibody, for aggressive CNSL. We report a patient with relapsed indolent CNSL who failed systemic rituximab and could not tolerate IT chemotherapies, but had an objective response of 6 months duration to IT rituximab.
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http://dx.doi.org/10.2217/cns.15.3 | DOI Listing |
Lancet Oncol
September 2025
Department of Neurosurgery, Mass General Brigham and Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Molecular aberrations have been incorporated into tumour classification guidelines of meningioma. TERT-promoter (TERTp) mutation is associated with worse prognosis and is designated a WHO grade 3 biomarker. However, it remains unclear whether TERTp mutation is context-dependent, with other co-occurring genetic alterations potentially driving its association with prognosis.
View Article and Find Full Text PDFANZ J Surg
September 2025
St. Vincent's Hospital, Sydney, Australia.
Background: Mucosa-associated lymphoid tissue (MALT) lymphoma in the central nervous system (CNS) is rare. As part of the non-Hodgkin B cell lymphoma group, it is much more indolent in presentation and progression than its aggressive cousin diffuse B-cell lymphoma (DBCL) of the CNS.
Methods: This systematic review collates all the published outcome and treatment data on CNS MALT to shed more light on this rare entity.
Taiwan J Ophthalmol
December 2024
Department of Ophthalmology, The Institute of Vision Research, Severance Eye Hospital, Yonsei University College of Medicine, Seoul, Korea.
Vitreoretinal lymphoma (VRL) is a rare ocular malignancy that involves the retina, the retinal pigment epithelium, and the vitreous. It is a subtype of primary central nervous system lymphoma (CNSL). Most cases of VRL and CNSL are classified as diffuse large B-cell lymphoma.
View Article and Find Full Text PDFCureus
April 2025
Pediatrics and Child Health, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, IND.
Cryptococcal meningoencephalitis is a grave and lethal form of an opportunistic infection usually occurring in immunocompromised patients (i.e., those with AIDS, organ transplant recipients, or those on immunosuppressive therapy) caused by species, namely which has a worldwide distribution, or which is predominantly found in tropical, subtropical, and temperate regions.
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March 2025
Hematology and Oncology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Marginal zone B-cell lymphoma (MZL) represents a heterogeneous group of indolent non-Hodgkin lymphomas (NHL) originating from the marginal zone of B cells in lymphoid tissues. Typically, MZL is classified as nodal, extranodal, and MZL with splenic involvement. Central nervous system (CNS) involvement is rare, whether it presents as a primary dural lymphoma or as a consequence of secondary CNS involvement.
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