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We present a rare case of intrahepatic cholangiocarcinoma (ICC) with multiple skeletal muscle metastases. The patient was a 55-year-old Asian woman presenting with abdominal pain; abdominal and pelvic computed tomography and magnetic resonance cholangiopancreatography revealed an unresectable ICC with hepatic metastasis and metastastatic lymphadenopathy in the porto-caval area. After 3 mo of treatment with palliative radiotherapy and chemotherapy, magnetic resonance imaging of the thoracolumbar spine detected right psoas muscle and paraspinous muscle metastases. We performed an ultrasound-guided percutaneous fine-needle biopsy that confirmed a similar pattern of poorly differentiated adenocarcinoma. The patient treated with palliative chemotherapy and achieved 10 mo of survival. Here we report the first case quickly spread to multiple sites of muscle even though the three-month treatment, compare to the other cases reported muscle metastases at diagnosis.
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http://dx.doi.org/10.3748/wjg.v21.i6.1989 | DOI Listing |
Int J Surg Pathol
September 2025
Department of Pathology, The Thirteenth People's Hospital of Chongqing, Chongqing, China.
Soft tissue sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Recent advancements in genomic profiling have identified novel gene fusions in these tumors, offering new insights into their pathogenesis and potential therapeutic targets. Here, we describe a spindle cell sarcoma harboring a novel gene fusion.
View Article and Find Full Text PDFUrol Case Rep
September 2025
Main Line Health, Division of Urology, Wynnewood, PA, USA.
Muscle-invasive bladder cancer (MIBC) with cardiac metastasis typically carries a very poor prognosis. A Black woman in her 70s developed high-grade urothelial carcinoma with squamous differentiation invading the bladder muscle. Despite chemotherapy, radiation, and nephrostomy, the disease progressed.
View Article and Find Full Text PDFIJU Case Rep
September 2025
Department of Urology Toyama University Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama Japan.
Introduction: The association between the risk of latent tuberculosis infection (LTBI) reactivation and immune checkpoint inhibitor (ICI) administration has been reported.
Case Presentation: A man in his seventies underwent robot-assisted laparoscopic radical cystectomy with ileal conduit diversion for muscle-invasive bladder cancer. Three years postoperatively, CT revealed metastases to the para-aortic lymph nodes and rectum.
HPB (Oxford)
August 2025
Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea. Electronic address:
Background: The appropriate extent of lymph node dissection has not yet been standardized in muscle-invasive gallbladder cancer.
Methods: Patients who underwent surgery, and were histologically diagnosed with muscle-invasive gallbladder cancer were included. Patients were classified as having Na, Nb, or Nc disease if their nodal metastases were limited to the porta hepatis and extended to the posterosuperior pancreatic head lymph nodes (PSPLNs), nodes along the celiac axis, or superior mesenteric vessels.
Mol Clin Oncol
November 2025
Department of Gastrointestinal Tumor Center, Beijing Arion Cancer, Beijing 102600, P.R. China.
Retroperitoneal leiomyosarcomas (RPLMS) are rare invasive malignant tumors originating from the smooth muscle of the retroperitoneum. Although metastasis mainly involves the lungs, liver and vascular regions, cutaneous metastasis is extremely rare, occurring in 1-2.6% of reported cases.
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