98%
921
2 minutes
20
Visual paradigms are versatile tools to investigate the pathophysiology of schizophrenia. Contextual modulation refers to a class of paradigms where a target is flanked by neighbouring elements, which either deteriorate or facilitate target perception. It is often proposed that contextual modulation is weakened in schizophrenia compared to controls, with facilitating contexts being less facilitating and deteriorating contexts being less deteriorating. However, results are mixed. In addition, facilitating and deteriorating effects are usually determined in different paradigms, making comparisons difficult. Here, we used a crowding paradigm in which both facilitation and deterioration effects can be determined all together. We found a main effect of group, i.e., patients performed worse in all conditions compared to controls. However, when we discounted for this main effect, facilitation and deterioration were well comparable to controls. Our results indicate that contextual modulation can be intact in schizophrenia patients.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.psychres.2015.01.009 | DOI Listing |
Psychol Rev
September 2025
Neural Computation Group, Max-Planck Institute for Human Cognitive and Brain Sciences.
It has been suggested that episodic memory relies on the well-studied machinery of spatial memory. This influential notion faces hurdles that become evident with dynamically changing spatial scenes and an immobile agent. Here I propose a model of episodic memory that can accommodate such episodes via temporal indexing.
View Article and Find Full Text PDFJ Nutr
September 2025
School of Medicine and Allied Health Sciences, University of The Gambia, Banjul, The Gambia; Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong 250
Background: Red and processed meat consumption is extensively linked to chronic disease risk in observational studies, with robust meta-analyses demonstrating significant positive associations for colorectal, breast, endometrial, and lung cancers, type 2 diabetes (T2DM), cardiovascular disease (CVD), and all-cause mortality. Dose-response relationships indicate elevated risks even at moderate intakes. Moreover, processed meats consistently show stronger detrimental effects than unprocessed red meats.
View Article and Find Full Text PDFNeuron
August 2025
Department of Biochemistry, University of Colorado, Boulder, CO, USA; Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA. Electronic address:
Tau aggregation is a hallmark of several neurodegenerative disorders, and the gain of toxic function of misfolded tau species is linked to pathobiology. Herein, we identified proteins that limit tau aggregation when targeted to tau aggregates by polyserine domains. Polyserine targeting was most effective at mitigating tau aggregation when fused to the vasolin-containing protein (VCP) adaptor protein fas-associated factor family member 2/UBX domain-containing protein 8 (FAF2/UBXD8).
View Article and Find Full Text PDFFront Aging Neurosci
August 2025
Scientific Institute, IRCCS E. Medea, Pasian di Prato, Udine, Italy.
Introduction: Predicting others' behaviors is an essential ability to interact efficiently within the social world. Previous evidence suggests that action prediction entails the integration of incoming sensory information with previous experience and contextual expectations. While it is well known that motor and cognitive functions face age-related changes, research examining how action prediction abilities evolve across the lifespan remains limited.
View Article and Find Full Text PDFbioRxiv
August 2025
Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Despite well-established cellular and molecular adaptations, opioid analgesic tolerance can be rapidly reversed in settings where these drugs are not expected. The specific neuronal populations that orchestrate this expectation-based tolerance remain poorly defined. In this study, we used a contextual tolerance training method alongside whole-brain clearing and immunostaining to identify brain regions involved in contextual tolerance and to pinpoint a specific neuronal ensemble in the ACC activated by this process.
View Article and Find Full Text PDF