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http://dx.doi.org/10.1093/bioinformatics/btv029 | DOI Listing |
Bioinformatics
November 2014
Division of Basic Sciences, University of Crete, Medical School, Heraklion 71110, Greece, Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Hellenic Centre for Marine Research (HCMR), Heraklion, Greece, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Cam
Summary: The iterative process of finding relevant information in biomedical literature and performing bioinformatics analyses might result in an endless loop for an inexperienced user, considering the exponential growth of scientific corpora and the plethora of tools designed to mine PubMed(®) and related biological databases. Herein, we describe BioTextQuest(+), a web-based interactive knowledge exploration platform with significant advances to its predecessor (BioTextQuest), aiming to bridge processes such as bioentity recognition, functional annotation, document clustering and data integration towards literature mining and concept discovery. BioTextQuest(+) enables PubMed and OMIM querying, retrieval of abstracts related to a targeted request and optimal detection of genes, proteins, molecular functions, pathways and biological processes within the retrieved documents.
View Article and Find Full Text PDFMethods Mol Biol
May 2015
Division of Basic Sciences, University of Crete Medical School, Heraklion, 71110, Greece.
Nowadays, it is possible to identify terms corresponding to biological entities within passages in biomedical text corpora: critically, their potential relationships then need to be detected. These relationships are typically detected by co-occurrence analysis, revealing associations between bioentities through their coexistence in single sentences and/or entire abstracts. These associations implicitly define networks, whose nodes represent terms/bioentities/concepts being connected by relationship edges; edge weights might represent confidence for these semantic connections.
View Article and Find Full Text PDFBioinformatics
December 2011
Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, CY 1678, Nicosia, Cyprus, Greece.
Summary: BioTextQuest combines automated discovery of significant terms in article clusters with structured knowledge annotation, via Named Entity Recognition services, offering interactive user-friendly visualization. A tag-cloud-based illustration of terms labeling each document cluster are semantically annotated according to the biological entity, and a list of document titles enable users to simultaneously compare terms and documents of each cluster, facilitating concept association and hypothesis generation. BioTextQuest allows customization of analysis parameters, e.
View Article and Find Full Text PDF