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Bisphosphonates have been commonly used for the treatment of osteoporosis. However, there have been recent case reports of atypical fractures citing their long-term use, which inhibits the turnover of bone components. A 64-year-old woman visited the outpatient clinic with pain in her right thigh and ambulation difficulty. We found fractures at both pedicles of L4 vertebra. subtrochanteric region of right femur, and left femoral shaft upon a radiologic examination. She had taken intravenous ibandronic sodium for osteoporosis over 3 years. We changed the bishophonates to a parathyroid hormone because it was suspected that the multiple fractures were caused by the medication. Further, rehabilitation, including progressive weight bearing, was started. After 3 months of the conservative treatment, she was able to walk independently. In conclusion, it is necessary to evaluate the possibility of atypical fractures in osteoporotic patients when they complain of lower extremity pain and to consider alternative treatments instead of bisphosphonates.
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http://dx.doi.org/10.1097/MD.0000000000000446 | DOI Listing |
Int J Surg Case Rep
August 2025
CHU Joseph Ravoahangy Andrianavalona, Service de Chirurgie Orthopédique et Traumatologique, 101 Tananarive, Madagascar.
Introduction And Importance: Monteggia lesions combine a fracture of the ulna with dislocation of the radial head. Monteggia-like variants add a radial head fracture. We report a unique Monteggia-like injury with a bifocal radial fracture and subcutaneous enucleation of the radial neck, which does not fit existing classifications.
View Article and Find Full Text PDFSkeletal Radiol
September 2025
Department of Radiology, Hospital do Coração (HCor), Rua Desembargador Eliseu Guilherme, 53, 7th floor. CEP, São Paulo, SP, 04004-03, Brazil.
Atypical proximal tibial fractures in adolescents are rare, particularly when linked to hormonal therapy for short stature. This case series reports the clinical and imaging features of atypical proximal tibial and distal femoral physeal fractures in male adolescents undergoing combined growth hormone (GH) and aromatase inhibitor (AI) therapy for idiopathic short stature. We report three cases of skeletally immature male adolescents (ages 12-16) treated with GH and anastrozole who presented with acute leg pain following low-energy trauma during soccer.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
General medicine department, Universidad de Cartagena, Cartagena, Colombia.
Background: Romosozumab is a sclerostin-inhibiting monoclonal antibody that is effective and safe for anabolic treatment in patients with osteoporosis. Its main adverse effects are local; the severity of these injection-site reactions in clinical trials was generally mild.
Case Report: We present a case of a 71-year-old Colombian woman with osteoporosis at very high risk of fractures with no relevant history of drug allergies.
Cureus
August 2025
Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.
Osteochondromas are the most common benign bone tumors and are frequently discovered incidentally in the metaphyseal regions of long bones during growth. While typically asymptomatic, they may occasionally lead to complications such as neurovascular impingement, mechanical irritation, or pathological fractures. Salter-Harris type II fractures represent the most frequent physeal injuries in pediatric populations, particularly in rapidly growing regions like the distal femur.
View Article and Find Full Text PDFCurr Osteoporos Rep
September 2025
NIHR Cambridge Biomedical Research Centre, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.
Purpose Of Review: In this review, we will examine the pathophysiology, anatomy, biochemistry, and genotype-phenotype correlation of femoral fractures in adult hypophosphatasia.
Recent Findings: Hypophosphatasia (HPP) is a rare genetic disease characterized by low activity of tissue-nonspecific alkaline phosphatase (TNAP). The disease presents a broad spectrum of clinical manifestations primarily determined by the degree of residual TNAP activity.