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http://dx.doi.org/10.3389/fnhum.2014.00877 | DOI Listing |
Eur J Neurosci
September 2025
Medical School Hamburg, ICAN Institute for Cognitive and Affective Neuroscience, Hamburg, Germany.
Despite the overwhelming prevalence of rodent-based research in neuroscience, with over 8700 studies published until March 2025 in the European Journal of Neuroscience alone (based on a targeted PubMed search using rodent-related keywords), one striking reality stands out: only a handful-24 studies-have explicitly addressed hemispheric asymmetries (using the same search with asymmetry-related terms). While this number is not exhaustive, it serves to exemplify the relatively limited focus on hemispheric lateralization in rodent studies. This notable gap in the literature highlights a pervasive underappreciation for the role of brain lateralization in rodents, a critical area of investigation that has been widely studied in human neuroscience but remains largely unexplored in animal models.
View Article and Find Full Text PDFJ Am Heart Assoc
September 2025
KHP Centre for Translational Medicine, King's College London British Heart Foundation, Cardiovascular Division, Department of Clinical Pharmacology St Thomas' Hospital London United Kingdom.
Background: The aim of this study was to investigate the associations between pulse pressure (PP) and age-related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions, microbleeds, cerebral blood flow and metabolism, and beta-amyloid accumulation.
Methods: Systematic review of PubMed (MEDLINE), Scopus, and Ovid Embase (from inception to January 2023) and references of included studies among adult populations was conducted. Findings were summarized narratively and by performing a fixed-effects meta-analysis.
Nat Commun
September 2025
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (Aβ) distribution (indicating greater hemisphere-specific vulnerability to AD pathology).
View Article and Find Full Text PDFDev Psychobiol
September 2025
Department of Psychology, Stanford University, Stanford, California, USA.
Early adversity is a well-established risk factor for psychopathology in youth. Contemporary taxonomies of adversity seek to distill the diverse stressors children face into meaningful categories of experience to enable more precise prediction of risk; however, few studies have tested these models using data-driven approaches in well-characterized, longitudinal samples. Here, we examined the latent structure of early stress across diverse domains of exposure, tested differential associations with psychopathology in adolescence, and investigated frontolimbic functional connectivity as a potential mediator.
View Article and Find Full Text PDFBehav Brain Res
August 2025
Department of Engineering Design, Indian Institute of Technology Madras, India. Electronic address:
Test Anxiety (TA) is known to impair the heart-brain interaction affecting both the central and autonomic nervous systems. The impairment is often assumed to be uniform, overlooking individual variability in stress response. This study explores how heart-brain dysregulation in TA may manifest conditionally, shaped by individual differences.
View Article and Find Full Text PDF