Structure and transfer of the vanA cluster in vanA-positive, vancomycin-susceptible Enterococcus faecium, and its revertant mutant.

Diagn Microbiol Infect Dis

Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.

Published: October 2014


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Article Abstract

Of 18 vanA-positive vancomycin-susceptible Enterococcus faecium isolates, vanRS in the vanA cluster was detected in all isolates, while vanHAX was detected in only 2 isolates. Following exposure to glycopeptides, 22.2% of vancomycin-susceptible E. faecium (VSE) converted into vancomycin-resistant E. faecium. The vanA cluster of the revertant mutant was transferred to the VSE isolates.

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http://dx.doi.org/10.1016/j.diagmicrobio.2014.06.012DOI Listing

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