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http://dx.doi.org/10.2450/2014.0248-13 | DOI Listing |
Arterioscler Thromb Vasc Biol
September 2025
Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, China. (Q.D., X.Z., L.F., A.C., Z.L., Y.Y., J.Z., X.L., Y.L., J.Y.).
Background: Vascular calcification is very common in patients with chronic kidney disease and contributes to the increased risk of cardiovascular events. NAMPT (nicotinamide phosphoribosyltransferase), the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide, has been shown to exert an antiaging effect on vascular smooth muscle cells. However, whether NAMPT is involved in the regulation of vascular calcification remains unclear.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Hematology, Jiaozuo People's Hospital, Jiaozuo, Henan, China.
Hairy cell leukemia variant (HCL-v) is a rare and more aggressive subtype of B-cell leukemia. While it shares certain clinical features with classical hairy cell leukemia (HCL-c), HCL-v typically follows a more malignant course and responds poorly to conventional therapies. We report a case of HCL-v in a 57-year-old male who was admitted with splenomegaly and abnormal blood counts.
View Article and Find Full Text PDFPlant Cell Environ
September 2025
College of Life Sciences, Northwest A&F University, Yangling, China.
The neuroactive β-N-oxalyl-L-α,β-diaminopropionic acid (β-ODAP) was first identified in Lathyrus sativus and present also in several Chinese traditional herbs including Panax notoginseng. It exhibit toxicological effects as the causative agent of neurolathyrism when L. sativus was over-consumed under drought-triggered famines or pharmacological effects including neuroprotection and wound healing.
View Article and Find Full Text PDFMath Biosci Eng
July 2025
Laboratory of Future Nanomedicines and Theoretical Chronopharmaceutics, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, Missouri 64108, USA.
Hes1 (Hairy and enhancer of split 1) is a transcriptional repressor that plays a fundamental role in the regulation of embryogenesis and cell lineage specification. The temporal dynamics of Hes1 mRNA and Hes1 protein expression are known to exhibit sustained oscillations. However, many existing mathematical models can reproduce these oscillations only transiently, eventually dampening toward a steady state.
View Article and Find Full Text PDFRadiol Case Rep
November 2025
Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA 92354, USA.
We present a case of a 59-year-old female with headaches and memory loss. Her history includes surgeries for hydronephrosis and a mediastinal mass initially diagnosed as retroperitoneal fibrosis. Imaging performed a few years later revealed multiple bilateral supratentorial masses.
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