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http://dx.doi.org/10.4088/JCP.14ac08982 | DOI Listing |
Expert Opin Pharmacother
September 2025
Department of Psychiatry, University of Calgary, Calgary, Alberta.
Introduction: Cannabis use disorder (CUD) is a growing global health concern, with limited pharmacological treatments currently available despite increasing prevalence and legalization trends.
Areas Covered: This review explores the landscape of pharmacotherapies for CUD, including both repurposed agents and emerging investigational compounds. We summarize findings from recent systematic reviews and meta-analyses, with attention to mechanisms of action and clinical relevance.
Front Public Health
September 2025
Department of Neurology, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, China.
Objective: To investigate the neural and molecular correlates of occupational burnout in nurses by integrating resting-state fMRI (rs-fMRI), clinical assessments, brain-wide gene expression, and neurotransmitter atlases.
Methods: Fifty-one female nurses meeting burnout criteria and 51 matched healthy controls underwent 3 T rs-fMRI. We analyzed fractional amplitude of low-frequency fluctuations (fALFF) and seed-based functional connectivity (FC), correlating findings with burnout (emotional exhaustion [EE], depersonalization [DP], and personal accomplishment [PA]).
Prostaglandins Other Lipid Mediat
September 2025
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Pharmacol Res Perspect
October 2025
Department of Nutritional Sciences, University of Georgia, Athens, Georgia, USA.
Exogenous cannabinoids have long been known to promote eating. However, the underlying mechanisms have not been completely elucidated, which is critical to understanding their utility. The orexin/hypocretin (OH) system of the lateral hypothalamus (LHA) has known anatomical, biochemical, and physiological interactions with the endocannabinoid system, and has an established role in promoting appetitive behavior; yet, it is still unknown if the OH system mediates food intake following cannabinoid administration.
View Article and Find Full Text PDFThe endocannabinoid (eCB) system-comprising cannabinoid receptors, eCBs (anandamide- AEA, 2-arachidonoylglycerol-2-AG) and related -acylethanolamines (NAEs; palmitoylethanolamide-PEA, and oleoylethanolamide-OEA), and metabolizing enzymes (e.g., fatty acid amide hydrolase; FAAH)-modulates nociceptive circuits in rodents.
View Article and Find Full Text PDF