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Stormwater management strategies increasingly recognise the need to emulate the pre-development flow regime, in addition to reducing pollutant concentrations and loads. However, it is unclear whether current design approaches for stormwater source-control techniques are effective in restoring the whole flow regime, and in particular low flows, towards their pre-development levels. We therefore modelled and compared a range of source-control stormwater management strategies, including some specifically tailored towards enhancing baseflow processes. The strategies were assessed based on the total streamflow volume and three low flow metrics. Strategies based on harvesting tanks showed much greater volume reduction than those based on raingardens. Strategies based on a low flow rate release, aimed at mimicking natural baseflow, failed to completely restore the baseflow regime. We also found that the sensitivity of the low flow metrics to the proportion of catchment treated varied amongst metrics, illustrating the importance of metrics selection in the assessment of stormwater strategies. In practice, our results suggest that realistic scenarios using low flow release from source-control techniques may not be able to fully restore the low flow regime, at least for perennial streams. However, a combination of feasibly-sized tanks and raingardens is likely to restore the baseflow regime to a great extent, while also benefitting water quality through the retention and filtration processes.
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http://dx.doi.org/10.2166/wst.2013.772 | DOI Listing |
Braz Oral Res
September 2025
Universidade de São Paulo - USP, Bauru School of Dentistry, Department of Biological Sciences, Bauru, SP, Brazil.
Angiotensin II (Ang II) releases inflammatory mediators from several cell types. The objective of this study was to investigate the potential of Ang II to induce mRNA expression of inflammatory mediators in primary cultured fibroblast-like cells isolated from gingival and periodontal ligament tissues. A synergistic effect of co-treatment with Ang II and Interleukin-1β (IL1β) on the mRNA expression of inflammatory mediators was explored.
View Article and Find Full Text PDFBraz Oral Res
September 2025
Universidade Estadual Paulista - Unesp, Araçatuba School of Dentistry, Department of Basic Science, Araçatuba, SP, Brazil.
The purpose of our review was to group the evidence and attempt to provide a consensus on the behavior of salivary flow rate in patients with Down syndrome. Observational studies evaluating salivary flow rate in children and teenagers with Down syndrome compared with non-syndrome individuals were selected. Ten sources of information were researched.
View Article and Find Full Text PDFCancer Immunol Res
September 2025
Alligator Bioscience (Sweden), Lund, Sweden.
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that targets CD40 and CEACAM5 developed for immunotherapy of cancer using the Neo-X-Prime platform.
View Article and Find Full Text PDFACS Synth Biol
September 2025
ARC Centre of Excellence in Synthetic Biology, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Fluorescent proteins (FPs) are commonly used as reporters to examine intracellular genetic, molecular, and biochemical status. Flow cytometry is a powerful technique for accurate quantification of single-cell fluorescent levels. Here, we characterize green, red, and blue FPs for use in yeast .
View Article and Find Full Text PDFERJ Open Res
September 2025
Division of Respiratory Medicine, Interventional Pulmonology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.
Background: The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of lymphoma has a low overall sensitivity. The lack of tissue architecture obtained by cytological needles decreases the diagnostic accuracy for diagnosis and subtyping of and relapsed mediastinal lymphomas. This study compares the sensitivity of EBUS-TBNA and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TMC) for both initial lymphoma diagnosis and recurrent cases, analyses safety, and evaluates the number of mediastinoscopies that could potentially be avoided due to this novel technique.
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