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Granulomatous dermatitis (GD) is known to occur following varicella-zoster virus (VZV) infection. Lesions may appear at varying times after the acute eruption in both immunosuppressed and immunocompetent hosts. The etiology of GD is unclear, and findings of VZV in the lesions often are inconsistent. We describe 2 immunocompromised patients who presented with GD following VZV infection; their lesions were examined for the presence of VZV. We also review the literature on postzoster GD.
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Am J Dermatopathol
September 2025
Department of Dermatology, Tufts Medical Center, Boston, MA.
Granulomatous vasculitis represents a rare cutaneous manifestation of sarcoidosis, a multisystem disease characterized by noncaseating granulomas. We report the case of a 28-year-old woman with new-onset tender, nonpruritic, erythematous papules coalescing into plaques and subcutaneous nodules on her lower legs, accompanied by anterior uveitis, exertional dyspnea, and constitutional symptoms including fatigue and night sweats. Punch biopsy revealed non-necrotizing epithelioid granulomas with vasculitic changes, consistent with cutaneous sarcoidal granulomatous vasculitis.
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August 2025
Department of Pediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
Background: Blau Syndrome is a rare monogenic disorder characterized by granulomatous polyarthritis, dermatitis, and uveitis. The diagnosis can be challenging as symptoms may not always align with the classic triad.
Case Description: An 8-year-old girl presented with fluctuant swellings in the wrists and ankles, strength reduction and stiffness.
JAMA Dermatol
August 2025
Kaplan-Amonette Department of Dermatology, University of Tennessee Health Science Center, Memphis.
Am J Dermatopathol
July 2025
Department of Pathology and Laboratory Medicine, Division of Anatomical Pathology, Nova Scotia, Canada.
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a relatively rare histopathologic reaction pattern that has been associated with several underlying conditions including rheumatoid arthritis, connective tissue disorders, certain drugs, and hematologic malignancies, particularly chronic myelomonocytic leukemia (CMML). CMML shows features of a myeloproliferative neoplasm and myelodysplastic syndrome. The diagnosis can be supported by identifying an acquired clonal molecular abnormality, most commonly involving TET2, SRSF2, ASXL1, RUNX1, NRAS, or CBL.
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