Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Humans with autoimmune peripheral neuropathies frequently harbour serum antibodies to single glycosphingolipids, especially gangliosides. Recently it has been appreciated that glycolipid and lipid complexes, formed from two or more individual species, can interact to create molecular shapes capable of being recognised by these autoantibodies whilst not binding to the single individuals. As a result of this, novel autoantibody targets have been identified. This newly termed 'combinatorial glycomic' approach has provided the impetus to redesigning the assay methodologies traditionally used in the neuropathy-associated autoantibody field. Combinatorial glycoarrays can be readily constructed in house using lipids of interest. Herein we especially highlight the role of the neutral lipids cholesterol and galactocerebroside in modifying glycosphingolipid orientation that subsequently favours or inhibits autoantibody binding.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cbpa.2014.01.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pioneering microbial synthesis of gangliosides in the filamentous fungus Ashbya gossypii.
Biotechnol Biofuels Bioprod
August 2025
Metabolic Engineering Group. Department of Microbiology and Genetics, Universidad de Salamanca, Salamanca, Spain.
Gangliosides are essential glycosphingolipids critical in neurodevelopment and cell signaling. Traditionally sourced from animal tissues, their production raises ethical concerns and faces challenges in scalability and cost. Chemoenzymatic methods have emerged as alternatives but lack flexibility and broad industrial applicability of microbial systems.
View Article and Find Full Text PDFThe Cytotoxic Potential of Humanized γδ T Cells Against Human Cancer Cell Lines in .
Cells
August 2025
InGenious Targeting Laboratory, 760-81 Coates Avenue, Holbrook, NY 11741, USA.
Cancer is a major global health issue, with rising incidence rates highlighting the urgent need for more effective treatments. Despite advances in cancer therapy, challenges such as adverse effects and limitations of existing treatments remain. Immunotherapy, which harnesses the body's immune system to target cancer cells, offers promising solutions.
View Article and Find Full Text PDFNovel glycan-related biomarker discovery by total glycomic and focused protein glycomic analyses.
J Hum Genet
August 2025
Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan.
The cell surface is covered with a variety of glycan subtypes (sub-glycans) such as N-glycans, O-glycans, glycosphingolipid-glycans, and glycosaminoglycans, which are collectively called the glycocalyx. The expression patterns of sub-glycans change in response to various biological events during disease pathogenesis; however, the structures of all major sub-glycans and their relative concentrations in a cell have been hardly reported. Total glycomic analysis, which comprehensively measures all major sub-glycans, is a powerful tool to discover cellular and clinical biomarkers.
View Article and Find Full Text PDFToF-SIMS revealing sphingolipids composition in extracellular vesicles and paternal β-cells after persistent hyperglycemia.
Talanta
July 2025
Department of Medical Physics, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University in Krakow, Poland; Centre for Theranostics, Jagiellonian University, Kopernika 40 St, 31-501, Krakow, Poland. Electronic address:
Extended periods of hyperglycemia (HG) can lead to dysfunction and metabolic disorders of sphingolipids (SPs) and their subsequent accumulation in cells. It can trigger a range of complications, including kidney and neurodegenerative diseases. We compared the levels of selected ceramides (CER), hexosylceramides (HexCER), and glycosphingolipids (GSLs) in potential HG biomarkers - extracellular vesicles (EVs).
View Article and Find Full Text PDFStabilization of milk-sphingomyelin gel phases by glycosphingolipids: An in-vitro study on the characteristics of milk sphingolipid gel phases.
Chem Phys Lipids
September 2025
Food Sciences, Department of Life Technologies, FI-20500 University of Turku, Turku, Finland. Electronic address:
Sphingolipids constitute a class of bioactive lipids essential for the structural and functional integrity of milk fat globule membrane (MFGM). Milk sphingomyelin (milk-SM), as a key component of MFGM, contributes to the stability of milk fat emulsions. Milk-SM and other sphingolipids, like glycosphingolipids (GSL), coexist in the same outer bilayer of MFGM, suggesting significant role of their interaction in shaping the structural properties and functions of MFGM.
View Article and Find Full Text PDF