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The linear [M(CN)2](-) (M = Au, Ag) anions can be used as metalloligands in oxime-based Mn chemistry to afford 1D chains of [Mn(III)6] single-molecule magnets (SMMs).
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http://dx.doi.org/10.1039/c3dt53502a | DOI Listing |
Arch Toxicol
August 2025
University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.
Organophosphorus compounds, including pesticides and nerve agents, irreversibly inhibit acetylcholinesterase, leading to an accumulation of acetylcholine that can cause a cholinergic crisis. Standard treatment of organophosphate poisoning relies on oxime-based reactivators, such as pralidoxime, obidoxime, or asoxime. However, these compounds have several limitations, including poor penetration through the blood-brain barrier and limited efficacy across a broad spectrum of organophosphorus compounds.
View Article and Find Full Text PDFChem Sci
February 2024
POLYMAT University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72 20018 Donostia-San Sebastian Spain
Oxime chemistry has emerged as a versatile tool for use in a wide range of applications. In particular, the combination of oximes with esters and urethanes has enabled the realisation of Covalent Adaptable Networks (CANs) with improved and tunable dynamic properties. Nevertheless, an exclusively oxime-based chemistry has not yet been explored in the fabrication of CANs.
View Article and Find Full Text PDFToxics
April 2022
Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (DSTL), Salisbury SP4 0JQ, UK.
The therapeutic efficacy of treatments for acute intoxication with highly toxic organophosphorus compounds, called nerve agents, usually involves determination of LD values 24 h after nerve agent challenge without and with a single administration of the treatment. Herein, the LD values of four nerve agents (sarin, soman, tabun and cyclosarin) for non-treated and treated intoxication were investigated in mice for experimental end points of 6 and 24 h. The LD values of the nerve agents were evaluated by probit-logarithmical analysis of deaths within 6 and 24 h of i.
View Article and Find Full Text PDFBiomolecules
March 2022
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing a concomitant anti-oxidant activity through dual-acting agents is now recognized as the gold standard treatment for preventing or at least delaying the progression of diabetic complications. Herein we describe a novel series of ()-benzaldehyde -benzyl oximes , , , and as ALR2 inhibitors endowed with anti-oxidant properties.
View Article and Find Full Text PDFPlant Direct
August 2020
Lima bean, , is a crop legume that produces the cyanogenic glucosides linamarin and lotaustralin. In the legumes and , the biosynthesis of these two α-hydroxynitrile glucosides involves cytochrome P450 enzymes of the CYP79 and CYP736 families and a UDP-glucosyltransferase. Here, we identify CYP79D71 as the first enzyme of the pathway in , producing oximes from valine and isoleucine.
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