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Background: Constraint-Induced Movement Therapy (CIMT) is an evidence-based rehabilitation intervention for stroke. Several factors influence the motor gain from CIMT, including age and level of impairment. However, it is currently unknown to what extent cognitive status affects motor gain during CIMT.
Objective: The aim of this study was to investigate whether cognitive and emotional status affects motor improvement during two weeks of CIMT and retention of the gain at three months follow-up.
Methods: Twenty stroke patients (3-12 months post stroke) completed two weeks of CIMT. Motor performance was measured using the Wolf Motor Function Test (WMFT). Cognitive and emotional status was measured with a comprehensive neuropsychological test battery and a questionnaire on emotional status. All measures were performed at baseline, after two weeks of training, and at three months follow-up.
Results: We found no significant correlation between cognitive or emotional measures at baseline and improvement in motor performance post training. Also, cognitive and emotional status did not correlate with motor retention at three months follow-up.
Conclusions: We found no evidence to support that cognitive performance in stroke patients can predict motor gain from CIMT.
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http://dx.doi.org/10.3233/NRE-131011 | DOI Listing |
Front Behav Neurosci
August 2025
Department of Sensory and Cognitive Physiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Sound influences motor functions and sound perception is conversely modulated by locomotion. Accumulating evidence supports an interconnection between the auditory system and the basal ganglia (BG), which has functional implications on the interaction between the two systems. Substantial evidence now supports auditory cortex and auditory thalamus inputs to the tri-laminar region of the tail of the striatum (tTS) in rodents.
View Article and Find Full Text PDFCortex
August 2025
University of Pittsburgh, Department of Ophthalmology, Pittsburgh PA 15219, USA; University of Pittsburgh, Department of Bioengineering, Pittsburgh PA 15213, USA.
The neural circuitry engaged in supporting eye movements has been well characterized, but fundamental questions remain about the necessity and sufficiency of the individual hemispheric contributions. To gain a better understanding of the neural correlates of oculomotor control, we measured horizontal smooth pursuit tracking behavior in 14 patients following childhood hemispherectomy. Relative to developmentally typical age-matched controls, patients exhibited a bilateral and asymmetric pursuit deficit with reduced ipsilesional but elevated contralesional eye speeds, and asymmetric accompanying 'catch up' saccades.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
This study aimed to characterize motor noise in human standing balance and uncover mechanisms that enable the nervous system to robustly sense and control upright posture despite this variability. We conducted three experiments using a robotic balance simulator. First, we quantified the natural variability of ankle torques, revealing that torque variability was stable within preferred postures and increased only at more extreme orientations.
View Article and Find Full Text PDFJ Neurophysiol
September 2025
School of Health and Human Sciences, Indiana University Indianapolis, Indianapolis, IN, USA.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can alter the excitability of targeted brain regions and influence motor learning. For the first experiment, we studied the effects of several individual stimulation montages (2mA) on motor learning in a complex rhythm-timing video game task (n=79, M1 anodal tDCS [M1 a-tDCS], Cerebellar anodal tDCS [CB a-tDCS], Cerebellar cathodal tDCS [CB c-tDCS], and SHAM). Performance was assessed using a performance index (PI) incorporating keystroke timing accuracy, tap distribution ratio, and key error rate.
View Article and Find Full Text PDFCerebellum
September 2025
Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Spinocerebellar ataxia type 27B (SCA27B), caused by GAA repeat expansions in FGF14, is an increasingly recognized form of late-onset cerebellar ataxia. However, early diagnosis remains challenging due to mild or absent cerebellar motor signs and often normal brain magnetic resonance imaging (MRI). Oculovestibular abnormalities, although prevalent, are frequently overlooked and not captured by standard clinical scales such as the Scale for the Assessment and Rating of Ataxia (SARA).
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