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Article Abstract
New heparin-indomethacin conjugate with an ester linkage was prepared by the carbodiimide-mediated condensation reaction, and then characterized by FTIR and (1)HNMR analyses. Due to its amphiphilic character, such a conjugate could self-aggregate into spherical nanoparticles in aqueous system, as confirmed by fluorescence spectroscopy, dynamic light scattering and transmission electron microscopy. By the in vitro drug release tests, the resultant conjugate nanoparticles were found to have a sustained and esterase-sensitive release behavior for conjugated indomethacin. In addition, the uptake of these conjugate nanoparticles into human nasopharyngeal carcinoma CNE1 cells was confirmed by fluorescence microscopy.
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| http://dx.doi.org/10.1016/j.msec.2013.09.024 | DOI Listing |
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New heparin-indomethacin conjugate with an ester linkage: synthesis, self aggregation and drug delivery behavior.
Mater Sci Eng C Mater Biol Appl
January 2014
DSAPM Lab and PCFM Lab, Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Article Synopsis
- A new heparin-indomethacin conjugate was created using a specific chemical reaction and characterized through various analytical methods.
- This conjugate has both hydrophilic and hydrophobic properties, allowing it to form spherical nanoparticles in water, as shown by multiple imaging techniques.
- When tested, these nanoparticles released indomethacin in a controlled and responsive manner and were successfully taken up by human cancer cells, indicating potential for drug delivery applications.