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Article Abstract
The water-soluble and biocompatible D-glucuronic acid coated Eu(OH)3 nanorods (average thickness x average length = 9.0 x 118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at approximately 600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 microM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be approximately 0.1 mM. Therefore, D-glucuronic acid coated Eu(OH)3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of approximately 1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.
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Surface coated Eu(OH)3 nanorods: a facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity.
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Article Synopsis
- The study introduces luminescent core-shell microspheres made of mesoporous SiO2 coated with europium hydroxide (Eu(OH)3), created through a simple one-pot synthesis at low temperatures.
- The resulting microspheres, with a total diameter of about 392 nm, exhibit strong red luminescence under UV light due to specific electronic transitions of the europium ions.
- The biocompatibility testing shows that these microspheres have low toxicity and are safe for use in applications such as bio-imaging, as demonstrated through various assays on human liver cells.