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Inspired by the exceptional climbing ability of gecko lizards, artificial fibrillar adhesives have been extensively studied over the last decade both experimentally and theoretically. Therefore, a new leap towards practical uses beyond the academic horizon is timely and highly anticipated. To this end, we present a fibrillar adhesive in the form of bridged micropillars and its application to a transportation system with the detachment mechanism inspired by the climbing behaviour of gecko lizards. The adhesive shows strong normal attachment (~30 N cm(-2)) as well as easy and fast detachment within 0.5 s without involving complex dynamic mechanisms or specific stimulus-responsive materials. The fabrication of the bridged micropillars consists of replica moulding of polydimethylsiloxane (PDMS) micropillars, transfer of the PDMS precursor to the heads of the micropillars, and inverse placement on an inert Teflon-coated surface. Owing to the spontaneous interconnections of low viscosity PDMS precursor, bridged micropillars with a uniform capping nanomembrane (~800 nm thickness) are formed over a large area. Interestingly, macroscopic adhesion in the normal direction can be immediately switched between on and off states by changing the two detachment modes of pulling and peeling, respectively. To prove the potential of the fibrillar adhesive for practical use, an automated transportation system is demonstrated for lifting and releasing a mass of stacked glass slides over 1000 cycles of attachment and detachment.
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http://dx.doi.org/10.1039/c3nr02008h | DOI Listing |
iScience
September 2025
Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, 67065 Strasbourg, France.
Platelet integrins, together with other platelet receptors, are known to control hemostasis and thrombosis but also metastatic progression. However, the impact of their exclusive but combined deficiency has never been tested in these processes. In a PF4Cre-β1/β3 mouse strain, we found that platelets were exclusively depleted of all integrins.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Viruses are versatile colloidal materials in their biofunctions, monodispersed and periodic structures, and high surface designability. For expanding the applicability of virus-based materials, spatiotemporally controlled immobilization and dispersion of viruses with retained activity should be useful, though control of the dynamic nature of viruses hybridized with commonly used polymers has been difficult due to their strong interactions. Here, we report a self-assembling peptide (A2Az) enabling photo control of adhesion and dispersion of M13 bacteriophage virus (M13 phage) and successfully demonstrate patterning of localization and infection of the virus.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Physics, Saveetha School of Engineering, SIMATS, Saveetha University, Chennai, Tamil Nadu, India.
Natural fibers are increasingly being explored as sustainable alternatives to synthetic materials in biocomposites, textiles, and biomedical applications. This study aims to extract and characterize natural fibers from Muntingia calabura twigs, evaluating their structural, mechanical, and biological properties for sustainable use. X-ray Diffraction (XRD) analysis revealed a 32.
View Article and Find Full Text PDFDifferentiation
September 2025
Centre for Stem Cell Research, (A unit of BRIC-InStem, Bengaluru), Christian Medical College, Vellore, India; Department of Physiology, Christian Medical College, Vellore, India. Electronic address:
Purpose: Fibronectin adhesion assay progenitors (FAA-CPs) and migratory assay progenitors (MCPs), subsets of mesenchymal-like stromal cells (MSCs), exhibit superior in-vitro chondrogenic potential compared to bone marrow (BM)-MSCs and chondrocytes. To assess this potential, differentiation studies followed by confirmatory staining for collagen deposition are utilized. Polarized light microscopy (PLM), based on birefringence principles, is a valuable tool for visualizing organized collagen fibers.
View Article and Find Full Text PDFJ Funct Biomater
July 2025
Centre for Regenerative Medicine and Devices, University of Brighton, Huxley Building Lewes Road, Brighton BN2 4GJ, UK.
The intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading. It comprises three tissues: the nucleus pulposus, the annulus fibrosus, and the end plates. Degeneration-related changes in the extracellular matrix of the nucleus pulposus upon ageing or pathological conditions prompted the present investigation into the impact of proteoglycan reduction, the main constituent of the healthy nucleus pulposus, on its physicochemical properties and cellular phenotypical changes.
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