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Sarcoidosis is a systemic granulomatous disease of unknown etiology that involves many organs, occasionally mimicking malignancy. We herein report a 50-yr-old woman of muscular sarcoidosis of chronic myopathic type, manifested by hypercalcemia and muscle wasting. Besides insignificant hilar lymphadenopathy, her sarcoidosis was confined to generalized atrophic muscles and therefore, F-18 FDG PET/CT alone among conventional imaging studies provided diagnostic clues for the non-parathyroid-related hypercalcemia. On follow-up PET/CT during low-dose steroid treatment, FDG uptake in the muscles disappeared whereas that in the hilar lymph nodes remained. PET/CT may be useful in the evaluation of unexpected disease extent and monitoring treatment response in suspected or known sarcoidosis patients.
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http://dx.doi.org/10.3346/jkms.2013.28.9.1399 | DOI Listing |
Intern Med
August 2025
Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan.
Clin Nucl Med
July 2025
Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Sarcoidosis is a systemic granulomatous disease of unknown etiology, primarily affecting the lungs and the lymphatics. Painless and impalpable diffuse sarcoid myopathy is very rare and may represent a diagnostic challenge even for expert physicians. We present the 18F-FDG PET/CT findings of a 77-year-old woman with muscular sarcoidosis manifested by non-parathyroid-related hypercalcemia.
View Article and Find Full Text PDFIntern Med
May 2025
Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan.
A 66-year-old woman who had been diagnosed with sarcoidosis 1 year prior to identifying a non-caseating granuloma in the nodule in her femur fell into a state of presyncope and had difficulty breathing. She was transported to the emergency department and placed on mechanical ventilation. A blood gas analysis suggested CO narcosis.
View Article and Find Full Text PDFNeuromuscul Disord
May 2025
Department of Neurology, Neuromuscular Reference Centre, Antwerp University Hospital, Antwerp, Belgium; Translational Neurosciences and Peripheral Neuropathy Group, University of Antwerp, Antwerp, Belgium; Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Antwerp, B
Chronic sarcoid myopathy is a rare disorder characterized by intramuscular granulomas and generally presents with symmetrical proximal limb-girdle muscle weakness. Here, we present an atypical case of a 68-year-old male with a history of pulmonary sarcoidosis with strikingly asymmetric limb-girdle weakness, progressive >20 years, including periscapular, paraspinal, lower limb and subtle facial involvement, mimicking facioscapulohumeral muscular dystrophy. MR images revealed a striking asymmetric pattern of patchy muscle involvement of paraspinal, lower limb and right periscapular muscles without marked muscle oedema.
View Article and Find Full Text PDFEur Heart J Case Rep
February 2025
Cardiology Department, Hospital de Santa Cruz, Avenida Prof. Dr. Reinaldo dos Santos, 2790-134 Lisbon, Portugal.
Background: Sarcoidosis is a rare inflammatory disease characterized by the presence of myocardial non-caseating granulomas. Heart failure, conduction abnormalities, and/or life-threatening arrhythmias are the main manifestations of cardiac sarcoidosis (CS). Cardiac magnetic resonance plays a major role in the diagnostic suspicion of cardiac involvement in sarcoidosis.
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