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http://dx.doi.org/10.1016/j.jmb.2013.07.031 | DOI Listing |
Nat Biotechnol
September 2025
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Antibody-drug conjugates (ADCs) are effective targeted therapeutics but are limited in their ability to incorporate less-potent payloads, varied drug mechanisms of action, different drug release mechanisms and tunable drug-to-antibody ratios. Here we introduce a technology to overcome these limitations called 'antibody-bottlebrush prodrug conjugates' (ABCs). An ABC consists of an IgG1 monoclonal antibody covalently conjugated to the terminus of a compact bivalent bottlebrush prodrug that has payloads bound through cleavable linkers and polyethylene glycol branches.
View Article and Find Full Text PDFObjectiveThis work examined performance costs for a spatial integration task when two sources of information were presented at increasing eccentricities with an augmented-reality (AR) head-mounted display (HMD).BackgroundSeveral studies have noted that different types of tasks have varying costs associated with the spatial proximity of information that requires mental integration. Additionally, prior work has found a relatively negligible role of head movements associated with performance costs.
View Article and Find Full Text PDFSci Prog
September 2025
Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China.
BackgroundGlaucoma is recognized as the second-leading cause of complete blindness in developed countries and a significant contributor to irreversible vision loss worldwide. Understanding the potential genetic links between neurodegenerative diseases, such as Parkinson's disease, and glaucoma is crucial for developing preventive strategies.MethodsThis study utilized data from Genome-Wide Association Studies databases, focusing on European populations without gender restrictions.
View Article and Find Full Text PDFTidsskr Nor Laegeforen
September 2025
Avdeling for bildediagnostikk, Sykehuset Østfold.
Background: Though rare, sphenoid sinusitis can cause abducens nerve palsy because of the anatomical proximity of the sphenoid sinus and the abducens nerve.
Case Presentation: A male patient in his late seventies presented with double vision and left abducens nerve palsy. Imaging revealed sinus opacifications later identified as due to Scedosporium apiospermum, a rare fungal pathogen.
Waste Manag Res
September 2025
Department of Economics, John Cabot University, Rome, Italy.
This research examines the impact of environmental (dis)amenities on residential rental values in the urban areas of Rawalpindi and Islamabad, Pakistan. Using a unique dataset of 849 households and geospatial data on 35 irregular dumpsites, we quantify how proximity to environmental disamenities depresses rental prices. Specifically, results confirm that irregular dumpsites significantly depress rental values, especially for properties situated near the closest distance rings.
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