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Electronic Health Records (EHRs) enable the sharing of patients' medical data. Since EHRs include patients' private data, access by researchers is restricted. Therefore k-anonymity is necessary to keep patients' private data safe without damaging useful medical information. However, k-anonymity cannot prevent sensitive attribute disclosure. An alternative, l-diversity, has been proposed as a solution to this problem and is defined as: each Q-block (ie, each set of rows corresponding to the same value for identifiers) contains at least l well-represented values for each sensitive attribute. While l-diversity protects against sensitive attribute disclosure, it is limited in that it focuses only on diversifying sensitive attributes. The aim of the study is to develop a k-anonymity method that not only minimizes information loss but also achieves diversity of the sensitive attribute. This paper proposes a new privacy protection method that uses conditional entropy and mutual information. This method considers both information loss as well as diversity of sensitive attributes. Conditional entropy can measure the information loss by generalization, and mutual information is used to achieve the diversity of sensitive attributes. This method can offer appropriate Q-blocks for generalization. We used the adult database from the UCI Machine Learning Repository and found that the proposed method can greatly reduce information loss compared with a recent l-diversity study. It can also achieve the diversity of sensitive attributes by counting the number of Q-blocks that have leaks of diversity. This study provides a privacy protection method that can improve data utility and protect against sensitive attribute disclosure. The method is viable and should be of interest for further privacy protection in EHR applications.
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http://dx.doi.org/10.2196/ijmr.2140 | DOI Listing |
Plant Dis
September 2025
Michigan State University, Department of Plant, Soil and Microbial Sciences, 105 CIPS, East Lansing, Michigan, United States, 48824;
Caliciopsis pinea is the ascomycete plant pathogen that causes caliciopsis canker disease on North American Pinus strobus (eastern white pine). Infections result in downgrading of lumber due to canker formation and overall loss of vigor in P. strobus, which is a critical cover species throughout its native range.
View Article and Find Full Text PDFOral Radiol
September 2025
Department of Oral and Maxillofacial Radiology, Eskisehir Osmangazi University, Meşelik Campus, Büyükdere Neighborhood, Prof. Dr. Nabi Avcı Boulevard No:4, Odunpazarı, Eskişehir, 26040, Turkey.
Objectives: The primary objective of this study is to evaluate the effectiveness of artificial intelligence-assisted segmentation methods in detecting carotid artery calcification (CAC) in panoramic radiographs and to compare the performance of different YOLO models: YOLOv5x-seg, YOLOv8x-seg, and YOLOv11x-seg. Additionally, the study aims to investigate the association between patient gender and the presence of CAC, as part of a broader epidemiological analysis.
Methods: In this study, 30,883 panoramic radiographs were scanned.
Leukemia
September 2025
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Pediatric acute myeloid leukemia (pAML) is a heterogeneous malignancy driven by diverse cytogenetic mutations. While identification of cytogenetic lesions improved risk stratification, prognostication remains inadequate with 30% of standard-risk patients experiencing relapse within 5 years. To deeply characterize pAML heterogeneity and identify poor outcome-associated blast cell profiles, we performed an analysis on 708,285 cells from 164 bone marrow biopsies of 95 patients and 11 healthy controls.
View Article and Find Full Text PDFCommun Med (Lond)
September 2025
Department of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surprising that to date, the extent of this complexity has not been systematically explored in high-burden countries of sub-Saharan Africa, especially in the reservoir of asymptomatic infections in all ages, which sustains transmission.
Methods: Here we take a metagenomic lens to these infections by sampling variable blood volumes from 188 afebrile residents living in high, seasonal transmission in Northern Sahelian Ghana.
Genes Genet Syst
September 2025
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Kyushu University.
In most eubacteria the initiator protein DnaA triggers chromosomal replication by forming an initiation complex at the origin of replication and also functions as a transcriptional regulator, coordinating gene expression with cell cycle progression. While DnaA-regulated genes are relatively well characterized in exponentially growing cells, its role in gene regulation during stationary phase remains insufficiently explored. Here, using an aquatic bacterium Caulobacter crescentus as a model, we show that C.
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