Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Glycogen synthase kinase-3 (GSK-3), a multifunctional serine-threonine kinase, is an important regulator in numerous signaling pathways and processes including adult brain neurogenesis. GSK-3 (mal)functioning was implicated in many diseases, in particular neurological and behavioral disorders. We investigated the impact of altered levels of the GSK-3β isoform on hippocampal size, number of doublecortin-positive cells, and hippocampal-dependent behaviors. Both GSK-3β transgenic mice (GSK-3β[S9A] mice) and GSK-3β neuron-specific knockout (GSK-3β(n-/-)) mice, showed reduced size of the dentate gyrus (DG) and were impaired in three hippocampal-dependent, species-typical behavioral tasks: digging, marble burying and nest building. We further demonstrate that the number of differentiating, doublecortin-positive new neurons is reduced in GSK-3β[S9A] mice, but not in GSK-3β(n-/-) mice. We conclude that GSK-3β activity must be critically controlled to allow wild type-like volume of the dentate gyrus and for normal execution of hippocampal-dependent, species-typical behavior.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbr.2013.03.045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.
Mol Psychiatry
September 2025
Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur St., Warsaw, 02-093, Poland.
Alcohol use disorder (AUD) is characterized by pathological motivation to consume alcohol and cognitive inflexibility, leading to excessive alcohol seeking and use. In this study, we investigated the molecular correlates of impaired extinction of alcohol seeking during forced abstinence using a mouse model of AUD in the automated IntelliCage social system. This model distinguished AUD-prone and AUD-resistant animals based on the presence of ≥2 or <2 criteria of AUD, respectively.
View Article and Find Full Text PDFDentate granule cell capacitance is stable across the light-dark cycle.
eNeuro
September 2025
Department of Neurobiology and McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL35294 and.
The plasma membrane acts as a capacitor that plays a critical role in neuronal excitability and signal propagation. Neuronal capacitance is proportional to the area of the cell membrane, thus is often used as a measure of cell size that is assumed to be relatively stable. Recent work proposes that the capacitance of dentate granule cells and cortical pyramidal cells changes across the light-dark cycle in a manner that alters synaptic integration.
View Article and Find Full Text PDFAdvances in intravital imaging of adult neurogenesis in mice.
Stem Cell Reports
September 2025
Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Electronic address:
The lifelong addition of stem-cell-derived neurons into distinct areas of the mammalian brain, such as the olfactory bulb and hippocampal dentate gyrus, provides structural and functional plasticity to neural circuits. To understand the dynamic processes underlying adult neurogenesis, from dividing stem/progenitor cells to integrating neurons, and to probe how new neurons shape brain function, intravital imaging turned out to be a powerful tool. Here, we review recent advances in the field of adult neurogenesis achieved by using in vivo imaging approaches in mice and discuss future directions of imaging-based experiments that will further our understanding of adult neurogenesis.
View Article and Find Full Text PDFBackground: Staphylococcus epidermidis (SE) is a predominant hospital-acquired bacterium leading to late-onset sepsis in preterm infants. Recent findings have suggested that postnatal S. epidermidis infection is associated with short-term neurodevelopmental consequences.
View Article and Find Full Text PDFCholinergic G protein-coupled bile acid receptor 1 (TGR5/GPBA) in the medial septal orchestrates adult hippocampal neurogenesis and cognition in Alzheimer's disease mice.
Br J Pharmacol
September 2025
Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Background And Purpose: The pathological role of the bile acid receptor TGR5/GPBA in Alzheimer's disease (AD) is not fully understood. We investigated the pharmacological effects and mechanisms of TGR5 in AD model mice.
Experimental Approach: TGR5 expression was assessed in AD mice using immunofluorescence and immunoblotting.