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Outcomes of second allogeneic stem cell transplantation and anti-relapse strategies in patients with relapsed/refractory acute myeloid leukemia: A unicentric retrospective analysis.
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Department of Hematology and Medical Oncology, University Medicine Göttingen (UMG), Göttingen, Germany.
Second allogeneic stem cell transplantation (allo-SCT2) represents a rescue option for selected patients (pts) with relapsed/refractory (r/r) acute myeloid leukemia (AML). Still, relapse rates post-allo-SCT2 remain high and effective anti-relapse strategies and predictive biomarkers remain to be defined. We here analyzed a cohort of 41 AML patients (pts) undergoing allo-SCT2 in our center.
View Article and Find Full Text PDF[Epigenetic cancer drugs and their role in anticancer therapy].
Vnitr Lek
June 2013
Interní klinika 1. lékařské fakulty UK a VFN v Praze.
Epigenetic modification have been causally linked to cancer development and progression, and are potentially reversible by treatments with epigenetic cancer drugs. The aim of this review is to give an overview of the basic current knowledge on molecular mechanisms of epigenetic cancer drugs and their possible clinical use. Many of them are in in clinical trials.
View Article and Find Full Text PDF[Production and characteristics of the growth and marker properties of mesenchymal stem cells of urinary bladder].
Zh Evol Biokhim Fiziol
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Mesenchymal stem cells (MSC) are capable for transdifferentiation into cells of another functional phenotype and are a perspective resourse of recovery therapy. MSC of different tissues differ by differentiation potential and in some cases express tissue-specific markers, which indicates close mesenchymal and parenchymal phenotypes of the same tissue. The homoorgan MSC might possibly be induced more effectively for tissue-specific differentiation and the preferred for cell therapy of diseases of the same organ as compared with widely used cells of the bone marrow origin.
View Article and Find Full Text PDFTreatment with 5-azacytidin upregulates the expression of CD20 in CD20-negative B cell acute lymphoblastic leukemia: a case report.
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Department of Hematology, Henri Mondor University Hospital, Créteil, France.
Epigenetic inactivation of PCDH10 in human prostate cancer cell lines.
Cell Biol Int
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Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen, Peoples Republic of China.
PCDH10 (protocadherin-10), a novel tumour suppressor gene, is down-regulated in several human cancers due to hypermethylation of promoter CGIs (CpG islands). Here, we investigated the expression of PCDH10 in different normal adult tissues and in a panel of prostate cancer cell lines. PCDH10 was widely expressed in normal tissues with higher levels in the prostate.
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