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Introduction of histidine units using benzotriazolide activation. | LitMetric

Introduction of histidine units using benzotriazolide activation.

J Pept Sci

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.

Published: February 2013


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Article Abstract

N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.

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http://dx.doi.org/10.1002/psc.2483DOI Listing

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