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South Chattanooga has been home to foundries, coke furnaces, chemical, wood preserving, tanning and textile plants for over 100 years. Most of the industries were in place before any significant development of residential property in the area. During the 1950s and 1960s, however, the government purchased inexpensive property and constructed public housing projects in South Chattanooga. Many neighborhoods that surround the Chattanooga Creek were previous dumping grounds for industry. Polycyclic aromatic hydrocarbons (PAHs) comprised the largest component of the dumping and airborne industrial emissions. To address the human exposure to these PAHs, a broad study of South Chattanooga soil contaminant concentrations was conducted on 20 sites across the city. Sixteen priority pollutant PAHs were quantified at two depths (0-10cm and 10-20cm) and compared against reference site soils, as well as to soils from industrially-impacted areas in Germany, China, and the US. From these data, the probability that people would encounter levels exceeding EPA Residential Preliminary Remediation Goals (PRG) was calculated. Results indicate that South Chattanooga soils have relatively high concentrations of total PAHs, specifically Benzo[a]pyrene (B[a]P). These high concentrations of B[a]P were somewhat ubiquitous in South Chattanooga. Indeed, there is a high probability (88%) of encountering soil in South Chattanooga that exceeds the EPA PRG for B[a]P. However, there is a low probability (15%) of encountering a site with ∑PAHs exceeding EPA PRG guidelines.
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http://dx.doi.org/10.1007/s11270-012-1265-7 | DOI Listing |
J Am Chem Soc
September 2025
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Iron homeostasis is essential for the virulence of the opportunistic fungal pathogen . The cytosolic monothiol glutaredoxin GrxD was recently shown to play a critical role in iron metabolism via regulation of iron-sulfur (Fe-S) binding iron-responsive transcription factors and interaction with components of the cytosolic Fe-S cluster assembly pathway. Interestingly, the putative copper-binding metallothionein CmtA was also identified as a binding partner for GrxD; however, the metal-binding properties of both proteins and the nature of their interactions were unclear.
View Article and Find Full Text PDFJ Neurointerv Surg
September 2025
Department of Neurosurgery, Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Background: The ESCAPE-MeVO (Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions) and DISTAL (Endovascular Therapy plus Best Medical Treatment vs Best Medical Treatment Alone for Medium Vessel Occlusion Stroke) trials failed to demonstrate the superiority of endovascular thrombectomy over best medical management for medium and small vessel occlusions. Potential limitations of these trials include older patient populations, lower presenting National Institutes of Health Stroke Scale (NIHSS) scores, higher rates of premorbid disability, delayed revascularization times, inclusion of both medium and small vessel occlusions, and widespread use of stent retrievers. Here we present M2 occlusion data from the Imperative Trial, evaluating aspiration thrombectomy with the Zoom System.
View Article and Find Full Text PDFJ Genet Eng Biotechnol
September 2025
Department of Biology, Geology and Environmental Science, University of Tennessee at Chattanooga, 615 McCallie Ave, Chattanooga, TN 37403, USA.
Kidney Renal Clear Cell Carcinoma (KIRC) is a leading cause of cancer death worldwide, but its early detection remains hindered by a lack of genetic markers. Our study aims to find prospective biomarkers that could serve as prognostic indicators and help in the identification of efficient drug candidates for KIRC treatment. Importantly, this study identifies the hub genes that play a crucial role in KIRC and their impact on male and female patients.
View Article and Find Full Text PDFEur Heart J Qual Care Clin Outcomes
August 2025
Centennial Heart at Parkridge, Parkridge Medical Center, Chattanooga, TN, USA.
Background: Racial disparities in outcomes for patients requiring temporary mechanical circulatory support (tMCS) after acute myocardial infarction (AMI) remain unclear.
Objective: To evaluate racial disparities in patients requiring tMCS following AMI.
Methods: Using the TriNetX US collaborative network (2009-2023), we identified non-Hispanic Black (NHB) and non-Hispanic White (NHW) adults who had AMI and required tMCS.
J Neurointerv Surg
July 2025
Department of Neurology and Neurosurgery, University of Pittsburgh Medical Center, UPMC Stroke Institute, Pittsburgh, Pennsylvania, USA
Background: Mechanical thrombectomy is the standard of care for large vessel occlusion (LVO) stroke, yet most device trials focus on individual technologies rather than complete systems.
Objective: To evaluate the safety and efficacy of the Zoom Reperfusion System compared with performance goals derived from a meta-analysis of trials using established thrombectomy technologies.
Methods: Prospective, multicenter, non-randomized, investigational device exemption trial conducted across 26 United States centers from October 2021 to March 2024.