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The management of newborns with extreme macrocephaly related to hydrocephalus can be difficult; balancing the treatment of severe cranial deformity with optimal hydrocephalus management can be complicated. Excessive CSF drainage can result in significant suture overlap that leads to difficulties in patient positioning, secondary synostosis, and long-term aesthetic complications. Delayed cranial reduction and remodeling procedures carry significant risk, and the aesthetic outcomes have sometimes been poor. The authors describe a newborn with severe macrocephaly who underwent shunt placement followed by a limited cranial reduction and fixation procedure using an absorbable plate within the 1st week of life. The procedure produced an immediate intracranial volume reduction of 49%. This novel management strategy facilitated patient positioning, simplified hydrocephalus management, and provided an excellent aesthetic outcome.
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http://dx.doi.org/10.3171/2012.10.PEDS12340 | DOI Listing |
Scand J Surg
September 2025
Department of Surgery, Sahlgrenska Hospital, Gothenburg, Sweden.
Background: In recent years, as new strategies have been developed, there has been a reduction of invasive interventions for prevention or treatment of ischaemic cerebral events. Furthermore, surgical treatment has been centralized to major vascular centra.
Aim: This study analyzed registered malpractice claims to the insurance during two decades.
Childs Nerv Syst
September 2025
Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, 1600 7TH Avenue South, Lowder 400, Birmingham, AL, 35233, USA.
Purpose: Diagnostic cerebral venograms are the gold standard for evaluating cerebral venous sinus stenosis (CVSS). Venous sinus stenting (VSS) and less commonly venous sinus angioplasty are emerging endovascular treatments in pediatric patients. This study examines the baseline intracranial venous pressures and postoperative endovascular outcomes in pediatric patients with CVSS.
View Article and Find Full Text PDFJ Leukoc Biol
September 2025
School of Pharmacy and Medical Science and Central Facility for Genomics, Griffith University, Parklands Drive, QLD, Australia.
There is limited understanding of the impact of anti-IL5 treatment on nasal polyp tissue biology in chronic rhinosinusitis with nasal polyps (CRSwNP). This study examined nasal polyp tissue cellular proteome and transcriptome responses to anti-IL5 treatment in CRSwNP utilising spatial profiling. GeoMx™ Digital Spatial Profiling (DSP) of 80 proteins and 1,833 mRNA targets in the polyp stroma and the whole transcriptome (18,815 mRNA targets) in polyp epithelia was undertaken on sinonasal biopsies collected from 20 individuals with eosinophilic CRSwNP before and after 16 and 24 weeks of mepolizumab treatment.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
September 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
Objective: To summarize the outcomes of 1000 consecutive microsurgical resection of cerebellopontine angle tumors.
Study Design: Retrospective cohort study.
Setting: Single tertiary care institution.
Facial Plast Surg
September 2025
ENT, Son Espases University Hospital, Palma, Spain.
Introduction Postoperative edema and fibrosis are key concerns following rhinoplasty, affecting outcomes and patient satisfaction. Triamcinolone acetonide (TA) is used for its proven anti-inflammatory and anti-fibrotic effects. Objective This study aims to evaluate the efficacy, usage profile, and safety of TA injections after rhinoplasty, focusing on postoperative edema and supratip fullness.
View Article and Find Full Text PDF