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Interactions between two vesicles in an imposed linear shear flow are studied theoretically, in the limit of almost spherical vesicles, with a large intervesicle distance, in a strong flow, with a large inner to outer viscosity ratio. This allows to derive a system of ordinary equations describing the dynamics of the two vesicles. We provide an analytic expression for the interaction law. We find that when the vesicles are in the same shear plane, the hydrodynamic interaction leads to a repulsion. When they are not, the interaction may turn into attraction instead. The interaction law is discussed and analyzed as a function of relevant parameters.
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http://dx.doi.org/10.1103/PhysRevE.86.011408 | DOI Listing |
J Sep Sci
September 2025
Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic.
The increasing use of engineered nanoparticles (NPs) in consumer and biomedical products has raised concern over their potential accumulation, transformation, and toxicity in biological systems. Accurate analytical methods are essential to detect, characterize, and quantify NPs in complex biological matrices. Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as a leading technique due to its high sensitivity, elemental selectivity, and quantitative capabilities.
View Article and Find Full Text PDFMol Pharm
September 2025
Department of Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, U.K.
We built a custom device to subject an antibody fragment A33 Fab to controlled stress conditions that combined pH, temperature, agitation, and LED-based light exposure in polypropylene microplates; to simulate the real-world challenges it may encounter during storage and transportation and to evaluate the key degradation routes in Fab formulations. We also explored the addition of Tween 80 as a surfactant and the impact of plate surface siliconisation. Monomer loss and fragmentation was monitored by size-exclusion chromatography, aggregate formation determined by changes in hydrodynamic radius in DLS, and chemical modifications identified through intact mass analysis by LC-MS, and N-terminal sequencing.
View Article and Find Full Text PDFLiver Int
October 2025
TGF-Beta and Cancer Group - Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Background And Aims: Hepatocellular carcinoma (HCC) has a poor prognosis and limited treatment options. TGF-β is a promising therapeutic target, but its dual role, as both a tumour suppressor and promoter, complicates its clinical application. While its effects on tumour cells are increasingly understood, its impact on the tumour stroma remains unclear.
View Article and Find Full Text PDFMed Eng Phys
October 2025
Department of Engineering Science, University of Oxford, United Kingdom. Electronic address:
Traditionally, clinical devices are designed, tested and improved through lengthy and expensive laboratory experiments and clinical trials [1]. More recently, computational methods have allowed for rapid testing, speeding up the design process and enabling far more complete searches of design space. While computational models cannot fully capture the complexities of biological systems, they provide valuable insights into crucial underlying mechanisms, such as the effects of fluid-structure interactions (FSIs).
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Engineering, University of Massachusetts Dartmouth, 285 Old Westport Road, Dartmouth, Massachusetts, 02747-2300, UNITED STATES.
Harbor seals possess a remarkable ability to detect hydrodynamic footprints left by moving objects, even long after the objects have passed, through interactions between wake flows and their uniquely shaped whiskers. While the flow-induced vibration (FIV) of harbor seal whisker models has been extensively studied, their response to unsteady wakes generated by upstream moving bodies remains poorly understood. This study investigates the wake-induced vibration (WIV) of a flexibly mounted harbor seal-inspired whisker positioned downstream of a forced-oscillating circular cylinder, simulating the hydrodynamic footprint of a moving object.
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