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Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell. | LitMetric
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Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.

Yi-Ting Chang , Pei-Yi Liao , Hwo-Shuenn Sheu , Yu-Jui Tseng , Fong-Yu Cheng , Chen-Sheng Yeh

Adv Mater

Department of Chemistry and Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan, 701 Taiwan.

Published: July 2012

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Article Abstract

Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.

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 Source
http://dx.doi.org/10.1002/adma.201200785DOI Listing

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