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To compare two different types of respiratory muscle training on exercise performance, a protocol was devised consisting of a combination of a 4-week, 12-session resistive respiratory muscle training (RRMT) followed by a 4-week, 12-session voluntary isocapnic hyperpnea training (VIHT) and conducted in experienced runners (4 men, 4 women). Measurements before and 5 days after training included: pulmonary function (spirometry), maximal inspiratory and expiratory mouth pressures, respiratory endurance time, maximal oxygen uptake (V(o2)max), running time to voluntary exhaustion at 80% V(o2)max, blood lactate concentration, and minute ventilation. There were no statistically significant differences in pulmonary functions and V(o2)max post-RRMT and post-VIHT compared to pre-RMT. Following RRMT the inspiratory muscle strength had improved by 23.8 +/- 30% and 18.7 +/- 21.4% at rest and immediately after the running test, respectively. RRMT did not increase the time intense voluntary isocapnic ventilation could be maintained during rest while VIHT increased it (237 +/- 207.8%). The duration of the endurance run was extended 17.7 +/- 6.5% after RRMT and 45.5 +/- 14.3% after VIHT.
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http://dx.doi.org/10.7205/milmed-d-11-00341 | DOI Listing |
Trop Doct
September 2025
Fellow in Pediatric Critical Care, Department of Pediatrics, Bharati Vidyapeeth (Deemed to be University), Pune, MH, India.
Tetanus is a rapidly progressive, life-threatening illness with the clinical hallmark of muscle spasms associated with respiratory and neurological sequelae, especially in the unimmunised population. Non-neonatal tetanus continues to be a rare diagnosis. We hereby report six cases admitted to our intensive care unit, highlighting the varied clinical features, management strategies and outcomes.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Ludwig Engel Centre for Respiratory Research, Westmead Hospital, Sydney, NSW, Australia.
Lung volume change modifies pharyngeal airway patency by altering breathing-related passive force transmission between lower and upper airways (via tracheal and other connections). We hypothesise that such force transmission may also impact active upper airway dilator muscle function by altering resting muscle length. The aim of this study was to determine the relationship between end expiratory lung volume (EELV) and ability of sternohyoid muscle (SH) contraction to alter pharyngeal airway patency.
View Article and Find Full Text PDFJMIR Form Res
September 2025
Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Provincial Geriatrics Institute, No. 106, Zhongshaner Rd, Guangzhou, 510080, China, 86 15920151904.
Background: Point-of-care ultrasonography has become a valuable tool for assessing diaphragmatic function in critically ill patients receiving invasive mechanical ventilation. However, conventional diaphragm ultrasound assessment remains highly operator-dependent and subjective. Previous research introduced automatic measurement of diaphragmatic excursion and velocity using 2D speckle-tracking technology.
View Article and Find Full Text PDFJTCVS Open
August 2025
Division of Congenital Heart Surgery, Department of Surgery, Texas Children's Hospital Heart Center and Baylor College of Medicine, Houston, Tex.
Objective: Pediatric pulmonary vein stenosis (PVS) is associated with substantial morbidity and mortality for the subset of patients with recurrent or progressive disease. The molecular mechanisms underlying the development and trajectory of PVS remain unclear. This study characterizes the transcriptome of clinical and phenotypic subtypes of PVS.
View Article and Find Full Text PDFOrphanet J Rare Dis
September 2025
Department of Neurology, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany.