Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy. | LitMetric

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Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy. | LitMetric

Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy.

Merritt C Maduke , Richard J Reimer

Neuron

Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive West, Stanford, CA 94305, USA.

Published: March 2012

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ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.

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