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http://dx.doi.org/10.1097/RLU.0b013e318239249f | DOI Listing |
Transpl Int
May 2025
Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Recipients of donation after circulatory death (DCD) kidneys are at high risk for delayed graft function (DGF) due to severe ischemia-reperfusion injury. We compared urinary biomarkers in predicting the duration of DGF with the tubular function slope (TFS) as the gold standard. In 89 DCD kidney transplant recipients, urinary TIMP-2, IGFBP7, B2M, NGAL, KIM1, CXCL9, and UMOD were quantified by LC-MS/MS analysis on postoperative days (PODs) 1, 4 and 10.
View Article and Find Full Text PDFEJNMMI Radiopharm Chem
March 2025
Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Background: Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are globally recognized as the primary choice for alleviating kidney pain and ureteric colic. This study examines the effects of long-term diclofenac administration on renography using two radiopharmaceuticals: 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), which is excreted almost exclusively by the renal tubules, and 99mTc-diethylenetriamine pentaacetic acid (99mTc-DTPA), which is predominantly excreted by glomerular filtration.
Results: Diclofenac administration caused a rightward shift in renograms, indicating delayed renal uptake and clearance for both tracers.
J Imaging
March 2025
Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
The objective of this study is to propose an advanced image enhancement strategy to address the challenge of reducing radiation doses in pediatric renal scintigraphy. Data from a public dynamic renal scintigraphy database were used. Based on noisier images, four denoising neural networks (DnCNN, UDnCNN, DUDnCNN, and AttnGAN) were evaluated.
View Article and Find Full Text PDFAppl Radiat Isot
June 2025
Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging, Geneva University Hospital, CH-1211, Geneva, 4, Switzerland.
It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the Tc-MAG3, Tc-DTPA, and Tc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old.
View Article and Find Full Text PDFClin Physiol Funct Imaging
March 2025
University Clinic in Nephrology and Hypertension, Department of Medicine, Gødstrup Hospital and Aarhus University, Herning, Denmark.
Background: Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([Tc]Tc-MAG3) clearance as a first attempt to validate Rb PET/CT for renal perfusion estimation using a reference method.
View Article and Find Full Text PDF