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http://dx.doi.org/10.1111/j.1365-2559.2011.04101.x | DOI Listing |
Bioengineering (Basel)
July 2025
Department of Urology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Prostate cancer remains one of the most prevalent malignancies among men, and emerging evidence proposed a potential role for periprostatic adipose tissue (PPAT) in tumor progression. However, its relationship with imaging-based risk stratification systems such as PI-RADS remains uncertain. This retrospective observational study aimed to evaluate whether periprostatic and subcutaneous fat thickness are associated with PI-RADS scores or PSA levels in biopsy-naïve patients.
View Article and Find Full Text PDFJ Transl Med
July 2025
Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina.
Prostate cancer (PCa) is the most prevalent cancer among men, highlighting the urgent need for innovative treatment strategies. The periprostatic adipose tissue (PPAT) plays a crucial role in the PCa tumor microenvironment, with direct crosstalk between PPAT and PCa cells, particularly in advanced stages with extraprostatic extension-a feature linked to poor prognosis. Owing to their migratory capacity, adipose stem cells (ASCs) are promising in regenerative medicine and play a key role in tissue engineering and cancer research.
View Article and Find Full Text PDFEur Urol
June 2025
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
Background And Objective: New anatomical studies have emerged since the last prostatic surgical anatomy review published in 2016. Our goal is to present the latest periprostatic anatomical understanding.
Methods: PubMed was queried to identify articles covering prostate anatomy, emphasizing work published from 2016 to 2025.
Investig Clin Urol
March 2025
Department of Urology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Purpose: To investigate the role of combined periprostatic nerve block (PNB) and intrarectal local anesthesia with heated lidocaine gel (ILAHL) in reducing pain during transrectal ultrasound (TRUS)-guided prostate biopsy, compared with PNB alone.
Materials And Methods: We performed a prospective randomized trial with 140 participants who underwent systematic TRUS-guided, 12-core prostate biopsy from July 2021 to June 2022. These participants were divided into two groups.
Cancers (Basel)
January 2025
Department of Urology and Andrology, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.
Periprostatic adipose tissue (PPAT) contributes to the pathogenesis of prostate cancer. The purpose of this study was to review and summarize the literature on the role of PPAT in prostate cancer pathogenesis. Moreover, we evaluated the clinical implication of PPAT in patients with prostate cancer.
View Article and Find Full Text PDF