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Objectives/hypothesis: The symptom of oscillopsia in patients with bilateral vestibular loss (BVL) can be reduced as dynamic visual acuity (DVA), the reduction in visual acuity during head movement, is improved by using real-time image stabilization, delivered by augmented reality eyewear.
Setting: Tertiary multidisciplinary neurotology clinic.
Study Design: Prospective experimental study.
Methods: Immersive virtual reality glasses used in combination with a compact digital video camera were used. A software algorithm was developed that used a center-weighted Lucas-Kanade optical flow method to stabilize video in real time. Six patients with BVL were tested for changes in DVA using the eyewear. The ability to read a Snellen chart during a 2-Hz oscillating head rotation DVA test was measured.
Results: For combined scores of vertical and horizontal head rotations, the mean number of lines readable at rest was 7.86, which dropped to 2.77 with head movement (a combination of vertical and horizontal perturbations). This increased to a mean of 6.14 lines with the image stabilization software being activated. This difference was statistically significant (P < .001).
Conclusion: This is the first successful attempt to improve dynamic visual acuity in patients with bilateral vestibular loss. Recent hardware upgrades are promising in improving these results even further.
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http://dx.doi.org/10.1177/0194599811434708 | DOI Listing |
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September 2025
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA; Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA.
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Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China. Electronic address:
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August 2025
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA. Electronic address:
Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as powerful tools in nanomedicine owing to their heavy-metal-free composition, distinct magnetic properties, biocompatibility, and customizable surface chemistry. While traditionally employed as T-weighted MRI contrast agents, recent innovations have enabled the development of ultra-small SPIONs-such as exceedingly small SPIONs (ES-SPIONs) and single-nanometer iron oxide nanoparticles (SNIOs)-that offer T-weighted MRI capabilities, which are favored by radiologists for their superior anatomical clarity. This review highlights the synthesis of monodisperse SPIONs via thermal decomposition and controlled oxidation, as well as their functionalization with zwitterionic dopamine sulfonate (ZDS) ligands, which confer colloidal stability, minimal protein adsorption, and efficient renal clearance.
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Durham University, Department of Physics, South Road, Durham DH1 3LE, United Kingdom.
The unabating discovery of nanoskyrmions in centrosymmetric magnets challenges the conventional Dzyaloshinskii-Moriya (DM) skyrmion stabilization mechanism. We investigate Gd_{2}PdSi_{3} using polarized resonant x-ray scattering and find that the low-field incommensurate modulations are elliptical helices, evolving into spin-density waves at higher fields. Quasi-2D magnetism arises via local DM interactions generated by inversion symmetry breaking around Gd-Gd bonds, which we characterize using atomistic simulations.
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