Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria. Here, we found that these hemoglobinopathies affected the trafficking system that directs parasite-encoded proteins to the surface of infected erythrocytes. Cryoelectron tomography revealed that the parasite generated a host-derived actin cytoskeleton within the cytoplasm of wild-type red blood cells that connected the Maurer's clefts with the host cell membrane and to which transport vesicles were attached. The actin cytoskeleton and the Maurer's clefts were aberrant in erythrocytes containing hemoglobin S or C. Hemoglobin oxidation products, enriched in hemoglobin S and C erythrocytes, inhibited actin polymerization in vitro and may account for the protective role in malaria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.1213775 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-range viscosity of the plasma membrane of a living cell measured by a shear-driven flow method.
Biophys J
September 2025
Department of Chromosome Science, National Institute of Genetics, Yata 1111, Mishima, 411-8540, Japan; Genetics Program, Sokendai, Yata 1111, Mishima, 411-8540, Japan.
The viscosity of the plasma membrane in living cells is a crucial biophysical parameter that regulates cellular functions. We categorize the plasma membrane viscosity into short-range and long-range viscosities based on the spatial scale of the cellular processes they influence. Short-range viscosity originates from the Brownian motion of membrane molecules, i.
View Article and Find Full Text PDFPlectin affects cell viscoelasticity at small and large deformations.
Biophys J
September 2025
Department of Bionanoscience and Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, 2629 HZ, The Netherlands. Electronic address:
Plectin is a giant protein of the plakin family that crosslinks the cytoskeleton of mammalian cells. It is expressed in virtually all tissues and its dysfunction is associated with various diseases such as skin blistering. There is evidence that plectin regulates the mechanical integrity of the cytoskeleton in diverse cell and tissue types.
View Article and Find Full Text PDFBiomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors.
Acta Biomater
September 2025
Faculty of medicine and health technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland. Electronic address:
In the eye, the retinal pigment epithelium (RPE) maintains the functionality and welfare of retinal photoreceptors and forms a tight, interlocked structure with photoreceptor outer segments (POSs). The RPE-retina interaction is difficult to recapitulate in vitro, limiting the studies addressing the retinal maintenance functions of the RPE. To overcome this challenge, we constructed a retina-mimicking structure using a soft polyacrylamide hydrogel coated with Matrigel.
View Article and Find Full Text PDFT cell activation is characterized by rapid reorganization of the actin cytoskeleton and cell spreading on the antigen presenting cell. The T cell nucleus occupies a large fraction of the cell volume, and its mechanical properties are likely to act as a key determinant of activation. However, the contribution of nuclear mechanics to T cell spreading and activation is not well understood.
View Article and Find Full Text PDFUnlabelled: Plasma membrane (PM) lipids and proteins are organized into nanoscale regions called nanodomains, which regulate essential cellular processes by controlling local membrane organization. Despite advances in super-resolution microscopy and single particle tracking, the small size and temporal instability of nanodomains make them difficult to study in living cells. To overcome these challenges, we built fluorescent DNA origami probes that insert into the PM via lipid anchors displayed on the cell.
View Article and Find Full Text PDF