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A comprehensive study of anaerobic digestion requires an advanced turbulence model technique to accurately predict mixing flow patterns because the digestion process that involves mass transfer between anaerobes and their substrates is primarily dependent on detailed information about the fine structure of turbulence in the digesters. This study presents a large eddy simulation (LES) of mechanical agitation of non-Newtonian fluids in anaerobic digesters, in which the sliding mesh method is used to characterize the impeller rotation. The three subgrid scale (SGS) models investigated are: (i) Smagorinsky-Lilly model, (ii) wall-adapting local eddy-viscosity model, and (iii) kinetic energy transport (KET) model. The simulation results show that the three SGS models produce very similar flow fields. A comparison of the simulated and measured axial velocities indicates that the LES profile shapes are in general agreement with the experimental data but they differ markedly in velocity magnitudes. A check of impeller power and flow numbers demonstrates that all the SGS models give excellent predictions, with the KET model performing the best. Moreover, the performance of six Reynolds-averaged Navier-Stokes turbulence models are assessed and compared with the LES results.
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http://dx.doi.org/10.1002/bit.24345 | DOI Listing |
Cont Lens Anterior Eye
September 2025
Keele University, Stafforshire, UK.
Purpose: To investigate associations between dry eye disease (DED) symptoms and psychological distress (depression, anxiety, stress) among undergraduate health sciences and nursing students in the Gaza Strip during the 2023-2025 conflict period.
Methods: A cross-sectional study used convenience sampling via WhatsApp and face-to-face interviews between 4 February and 29 April 2025. Participants completed a demographic form, the Arabic Ocular Surface Disease Index (OSDI), and the Arabic Depression Anxiety Stress Scale-8 (DASS-8).
Cureus
August 2025
Department of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, CHN.
Sjögren's syndrome (SS) is an autoimmune disease characterized by the destruction of the structure and function of exocrine glands (EGs) such as lacrimal glands (LGs) and salivary glands (SGs). During the pathogenesis, various immune cells such as lymphocytes, dendritic cells, and macrophages are activated, which together maintain the pro-inflammatory environment of the EGs. As an important immune cell linking innate and specific immunity, macrophages have both functions of phagocytosis and antigen presentation.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
University of San Francisco, Department of Nursing and Health Professions, San Francisco, California, United States; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Department of Epidemiology, Fielding School of Public Health, University of California, Los A
Objectives: To quantify the incidence of adverse events given COVID-19 vaccination and COVID-19 diagnosis in women of reproductive age; to examine pregnancy as a potential risk modifier.
Methods: An exposure-matched cohort study of >1 million women, 11 December 2020-30 September 2022, United States. COVID-19 vaccination, COVID-19 diagnoses, and medically-attended adverse events - including immunologic, neurologic, cerebrovascular, thromboembolic, cardiovascular, respiratory, thrombocytopenic and coagulative events - were identified from inpatient and outpatient medical claims.
FEBS Lett
September 2025
Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Germany.
Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by motor neuron degeneration. Hexanucleotide repeat expansions in the C9orf72 gene, the most common genetic cause of ALS (C9-ALS), drive toxicity through different mechanisms. These pathological changes include alterations in stress granules (SGs), ribonucleoprotein complexes formed under stress conditions.
View Article and Find Full Text PDFCytokine
August 2025
Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:
Background: Primary Sjögren disease (pSjD) is an autoimmune disorder that primarily targets the lacrimal glands (LGs) and salivary glands (SGs). However, the differences in immune pathogenesis between LGs and SGs remain poorly understood. In this study, we investigated LG-specific immune responses in comparison to SGs using a murine model of pSjD.
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