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A 36-year old man, having injured himself severely by smashing windows in a rage of fury, was arrested by the police. He died despite resuscitation attempts. The forensic autopsy showed many superficial skin lacerations, bruises and minor brain swelling, but there was no definitive cause of death. Toxicological analysis showed a high concentration of mephedrone in femoral blood (5.1mg/L) and traces of cocaine, MDMA and oxazepam. The remaining dose of mephedrone in the stomach contents was estimated at 113 mg. Tablets that were found in the house of the deceased also contained mephedrone. We attribute this man's death to a fatal oral intake of mephedrone, which probably led to a state of excited delirium. This was aggravated by blood loss from multiple wounds.
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http://dx.doi.org/10.1016/j.forsciint.2010.12.014 | DOI Listing |
Int J Drug Policy
August 2025
Amsterdam UMC, Department of Psychiatry, University of Amsterdam, Meibergdreef 9, Amsterdam, Netherlands; Amsterdam Neuroscience, Research Program Compulsivity, Impulsivity & Attention, Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, the Netherlands.
Background And Aims: Use of the synthetic methylmethcathinones 2-MMC and 3-MMC (2/3-MMC) is emerging, especially among young people, but their health risks remain unclear.
Method: A systematic narrative review was conducted on studies describing the availability, pharmaco-toxicological profile, and user characteristics of 2/3-MMC, with a focus on the situation in The Netherlands.
Results: Among nightlife youth (16-35 yrs.
J Chromatogr A
October 2025
Istanbul University- Cerrahpaşa, Institute of Forensic Sciences and Legal Medicine, Department of Medicine, Buyukcekmece, 34500 Istanbul, Türkiye.
Identifying trends in psychoactive substance use is essential for developing effective public health policies. Wastewater-based epidemiology (WBE) offers an objective and rapid approach to monitoring illicit drugs and new psychoactive substances (NPS). Given the continuous evolution of the drug market, it is crucial to establish analytical methods that can simultaneously analyze both conventional illicit drugs and emerging NPS.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
New psychoactive substances (NPSs) have emerged as a significant global public health challenge due to their ability to mimic traditional drugs. Among these, mephedrone has gained attention because of its widespread use and associated toxicities. This review provides a comprehensive analysis of the structure, pharmacokinetic properties, and metabolic pathways of mephedrone, highlighting its phase I and phase II metabolites as potential biomarkers for detection and forensic applications.
View Article and Find Full Text PDFInfect Dis Ther
August 2025
HIV Unit, Infectious Diseases Service, Hospital Clinic, IDIBAPS AIDS and HIV Research Group, Barcelona University, Villarroel 170, 08036, Barcelona, Spain.
Introduction: Chemsex, the intentional use of drugs to enhance sexual experiences among gay, bisexual, and other men who have sex with men (gbMSM), is linked to high-risk sexual behaviours and increased sexually transmitted infections (STIs). Data on its long-term evolution after implementing specific strategies in HIV settings are limited. We evaluated the incidence of drug use, sexual behaviour, STIs, and vulnerabilities over 3 years following a specific approach at the HIV Unit of Hospital Clinic in Barcelona, Spain.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
November 2025
School of Forensic Sciences, National Forensic Sciences University, Gujarat, India.
Rationale: The rapid emergence and structural diversity of new psychoactive substances (NPS) present significant challenges for forensic drug analysis. Existing targeted methods often fall short in accurately identifying novel compounds, increasing the risk of false positives or missed detections. This study aims to address this gap by developing a robust, non-targeted analytical approach capable of confidently screening, identifying, and confirming a broad range of NPS.
View Article and Find Full Text PDF