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Age-related differences in cardiogenic shock secondary to Takotsubo syndrome.
Eur J Clin Invest
September 2025
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS).
Methods And Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%).
Left ventricular function recovery in Takotsubo syndrome, clinical and pathophysiological insights: a state-of-the-art review.
Curr Opin Cardiol
August 2025
Department of Cardiology, Hospital Universitario de Torrejón, Ribera Salud Group. Madrid, Spain and Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain.
Purpose Of Review: Early (<10 days) recovery of the left ventricular ejection fraction (LVEF) in Takotsubo syndrome (TTS) has been associated with better short- and long-term clinical outcomes compared to delayed recovery (>10 days). This review aims to comprehensively address the literature regarding its clinical implications, the pathological basis underlying a chronic inflammatory heart failure phenotype; as well as the potential pharmacological and nonpharmacological therapies that might aid in LVEF recovery and improve clinical outcomes in TTS.
Recent Findings: We describe the clinical findings of the two large studies addressing this topic, derived from ongoing prospective registries (RETAKO and InterTAK) in which inflammatory biomarkers are the strongest independently associated factor with late left ventricular (LV) recovery (>10 days).
Use of Serotonin and Catecholamine Reuptake Inhibitors and Onset of Takotsubo Syndrome.
Biopsychosoc Sci Med
August 2025
Objective: Takotsubo Syndrome (TS), is an acute, transient heart failure primarily affecting older women. Excessive sympathetic stimulation from emotional or physical stressors is assumed to trigger TS through a toxic surge in plasma catecholamines. Case reports have signaled the onset of TS following treatment with serotonin and catecholamine reuptake inhibitors.
View Article and Find Full Text PDFA case of a broken heart: takotsubo cardiomyopathy following anaesthetic induction.
Cardiol Young
August 2025
Department of Pediatrics, Division of Cardiology, University of California, San Diego Rady Children's Hospital, San Diego, USA.
Takotsubo cardiomyopathy, also known as stress cardiomyopathy or broken heart syndrome, is named for echocardiographic features that look like the "tako-tsubo" (octopus trap). While classically associated with older women after experiencing significant emotional distress, it can also occur in paediatrics. Our patient is an 11-year-old male with a complex medical history who developed Takotsubo cardiomyopathy after cardiac arrest during anaesthesia induction.
View Article and Find Full Text PDFCardiovascular Complications of COVID-19 Disease: A Narrative Review.
Diseases
August 2025
Division of Cardiology, Parma University Hospital, 43126 Parma, Italy.
Background: The coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has had a profound impact on global health, extending beyond pulmonary complications. Cardiovascular involvement in COVID-19 is multifactorial and may be influenced by viral load, inflammatory response, and pre-existing comorbidities.
Discussion: Acute complications include myocardial injury, arrhythmias, acute coronary syndromes (ACS), heart failure, Takotsubo cardiomyopathy, myopericarditis, and cardiac arrest.