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Laboratory research using songbirds as a model system for investigating basic questions of neurobiological function has expanded rapidly and recently, with approximately 120 laboratories working with songbirds worldwide. In the United States alone, of the approximately 80 such laboratories nearly a third have been established in the past 10 years. Yet many animal facilities are not outfitted to manage these animals, and as a consequence laboratories often use alternative housing arrangements established by institutional animal care and use committees (IACUCs). These committees invariably differ in their expertise level with birds and thus guidelines also vary considerably from one institution to another. In this article I address a number of factors to consider for effective oversight of research involving songbirds.
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http://dx.doi.org/10.1093/ilar.51.4.424 | DOI Listing |
Eur J Med Res
August 2025
Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Age-related Macular Degeneration (AMD) is widely acknowledged as a principal cause of vision loss in the elderly. Currently, the therapeutic interventions available in clinical practice fail to achieve satisfactory outcomes. Therefore, it is imperative that we approach the progress of AMD from novel perspectives in order to explore new therapeutic strategies.
View Article and Find Full Text PDFBMC Microbiol
July 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a significant global health threat, associated with high morbidity and mortality rates among hospitalized patients. The interaction between MDR-KP and its host is highly complex, and few studies have investigated these interactions from both the pathogen and host perspectives. Here, we explored these interactions in a mouse model of pneumonia using dual RNA-seq analysis.
View Article and Find Full Text PDFClin Epigenetics
July 2025
State Key Laboratory of Druggability Evatuation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, 300301, China.
Purpose: To evaluate the efficacy of sorafenib in combination with the DNA methylation inhibitor decitabine (DAC) for the treatment of hepatocellular carcinoma (HCC), and to investigate the mechanism of sorafenib resistance from an epigenetic perspective, aiming to provide new insights and strategies for HCC therapy.
Methods: The GEPIA2 database was used to analyze the expression of solute carrier organic anion transporter family member 1B3 (SLCO1B3) in various tumors and adjacent normal tissues. The Kaplan-Meier method was applied to assess the relationship between SLCO1B3 expression and overall survival.
Oncogene
September 2025
Medical Department, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Province, China.
Colorectal cancer (CRC) is a severe health risk, and while Cetuximab is a key treatment, resistance due to KRAS mutations poses a challenge. The role of ALKBH5, often overexpressed in cancers, in KRAS-mutated CRC and its resistance to Cetuximab is not yet fully understood. This research initiates an inquiry from both cellular and animal experimental perspectives, investigating the potential of ALKBH5 to confer resistance to Cetuximab in colorectal cancer cells harboring KRAS mutations.
View Article and Find Full Text PDFBMC Nurs
July 2025
Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211, Finland.
Background: Family support during acute illnesses is both a care quality indicator and a goal to deliver value-based care that is respectful of patients and their families' needs. The aim of this study was to assess the level of perceived family support (i.e.
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